Fine-needle Aspiration of Thyroid Nodules: Is it Worth Repeating?

Authors

  • Vera Fernandes Serviço de Endocrinologia. Hospital de Braga. Braga. Portugal. ICVS - Instituto de Investigação em Ciências da Vida e Saúde. Escola de Ciências da Saúde. Universidade do Minho. Braga. Portugal. ICVS/3Bs - PT Government Associate Laboratory. Braga/Guimarães. Portugal. http://orcid.org/0000-0002-9043-3867
  • Tânia Pereira IPATIMUP Diagnósticos. Instituto de Patologia e Imunologia Molecular. Universidade do Porto. Porto. Portugal.
  • Catarina Eloy IPATIMUP Diagnósticos. Instituto de Patologia e Imunologia Molecular. Universidade do Porto. Porto. Portugal. Departamento de Patologia. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

DOI:

https://doi.org/10.20344/amp.8215

Keywords:

Biopsy, Fine-Needle, Thyroid Nodule

Abstract

Introduction: The fine-needle aspiration has a significant role in assessing the malignancy risk of thyroid nodules. There is uncertainty regarding the value of repeat fine-needle aspiration in benign nodules. This study aims to evaluate the concordance of results in consecutive fine-needle aspiration and to study the relevance of repetition in benign results.
Material and Methods: Retrospective study of the 4800 thyroid nodules fine-needle aspiration held in Instituto de Patologia e Imunologia Molecular da Universidade do Porto between January 1, 2014 and May 2, 2016. Of the initial sample, we selected the repeated fine-needle aspiration on the same nodule.
Results: The first fine-needle aspiration result of the 309 nodules underwent revaluation was non-diagnostic in 103 (33.3%), benign in 120 (38.8%) and atypia/follicular lesion of undetermined significance in 86 (27.8%). The agreement between the first and second fine-needle aspiration was significantly higher in cases with an initial benign result (benign: 85.8%, non-diagnostic: 27.2% and atypia/ follicular lesion of undetermined significance: 17.4%, p < 0.005). The fine-needle aspiration repeating motifs in initially benign nodules (n = 78) were repetition suggestion in 58, nodule growth in 17 and suspicious ultrasonographic features in 3.
Discussion: The fine-needle aspiration repetition in nodules with initial non-diagnostic and atypia/follicular lesion of undetermined significance result changed the initial diagnosis in a significant proportion of patients, modifying their therapeutic approach. The high concordance of results in initially benign nodules makes fine-needle aspiration repetition not cost-effective in most cases.
Conclusion: The fine-needle aspiration should be repeated when the initial cytology result is non-diagnostic or atypia/follicular lesion of undetermined significance.

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Published

2017-06-30

How to Cite

1.
Fernandes V, Pereira T, Eloy C. Fine-needle Aspiration of Thyroid Nodules: Is it Worth Repeating?. Acta Med Port [Internet]. 2017 Jun. 30 [cited 2024 Nov. 22];30(6):472-8. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/8215

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Original