Dear Editor,
Since the first international alert on the 5th April 2022 and the ongoing news, probable cases of hepatitis of unknown origin have been reported in children worldwide. The etiology and pathogenic mechanisms of the disease remain under investigation, and so far the evidence suggests adenovirus or SARS-CoV-2 as being the most likely infectious causes, although toxins, drugs or environmental exposures have been considered as well. Further hypotheses point out a novel pathogen or variant of adenovirus or SARS-CoV-2.¹ In Portugal, according to the most recent data from the European Centre for Disease Prevention and Control (ECDC), published on the 1st July there are only 19 suspected cases.²

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