A Rare Case of Spontaneous Remission and Relapse of a Primary Central Nervous System Lymphoma

Authors

  • Rui Ramos Departamento de Neurocirurgia. Hospital de Braga. Braga.
  • João Soares Fernandes Departamento de Neurorradiologia. Hospital de Braga. Braga.
  • Marta Almeida Departamento de Oncologia. Hospital de Braga. Braga.
  • Rui Almeida Departamento de Neurocirurgia. Hospital de Braga. Braga.

DOI:

https://doi.org/10.20344/amp.10198

Keywords:

Central Nervous System Neoplasms/drug therapy, Central Nervous System Neoplasms/radiotherapy, Lymphoma/drug therapy, Lymphoma/radiotherapy

Abstract

Primary central nervous system lymphoma remission after steroid treatment is a well-known phenomenon, but remission without any type of treatment is extremely rare. We present a rare case of spontaneous remission of a diffuse large B-cell lymphoma of the central nervous system as well as its subsequent reappearance in another location. The atypical presentation misled the neurosurgeons and neurologists, delaying diagnosis and treatment. The patient underwent brain biopsy after the relapse and started radiotherapy and chemotherapy with cytarabine + methotrexate + rituximab. As of 32 months after the diagnosis, the patient remained asymptomatic, with no focal neurological deficits and the disease in complete remission. A PubMed search of the literature up to June 2017 regarding spontaneous remission central nervous system lymphoma was also carried out.

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Published

2018-12-28

How to Cite

1.
Ramos R, Fernandes JS, Almeida M, Almeida R. A Rare Case of Spontaneous Remission and Relapse of a Primary Central Nervous System Lymphoma. Acta Med Port [Internet]. 2018 Dec. 28 [cited 2023 Feb. 8];31(12):777-83. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/10198

Issue

Section

Case Report