Whipple disease and central nervous system.

Authors

  • Pedro Abreu Serviço de Neurologia, Hospital de S. João, Porto.
  • Elsa Azevedo
  • Luís Lobo
  • Conceição Souto Moura
  • Celso Pontes

DOI:

https://doi.org/10.20344/amp.1023

Abstract

Whipple disease (WD) is a rare systemic infection caused by the bacteria Tropheryma whipplei. Slowly progressive dementia, supranuclear ophthalmoplegia, headache, myoclonus, hypothalamic dysfunction, oculomasticatory-skeletal myorythmia are characteristic manifestations when WD involves the central nervous system (CNS). Treatment of cerebral WD should be performed with antibiotics that reach the CNS for at the least one-year. We alert for the early diagnosis of WD in patients with exclusively neurological clinical pictures, sometimes with atypical or non-definitive diagnosis, because it is a potential treatable disease.

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How to Cite

1.
Abreu P, Azevedo E, Lobo L, Moura CS, Pontes C. Whipple disease and central nervous system. Acta Med Port [Internet]. 2005 Jun. 30 [cited 2022 Dec. 7];18(3):199-208. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/1023

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Section

Arquivo Histórico