Hospitalizations due to Angioedema without Urticaria in a Portuguese Center: Five Year Retrospective Study

Authors

  • Joana Cosme Serviço de Imunoalergologia. Hospital de Santa Maria. Centro Hospitalar Universitário de Lisboa Norte. Lisboa.
  • Amélia Spínola Serviço de Imunoalergologia. Hospital de Santa Maria. Centro Hospitalar Universitário de Lisboa Norte. Lisboa.
  • Manuel Branco Ferreira Serviço de Imunoalergologia. Hospital de Santa Maria. Centro Hospitalar Universitário de Lisboa Norte. Lisboa. Clínica Universitária de Imunoalergologia. Faculdade de Medicina. Universidade de Lisboa. Lisboa.
  • Manuel Pereira Barbosa Serviço de Imunoalergologia. Hospital de Santa Maria. Centro Hospitalar Universitário de Lisboa Norte. Lisboa. Clínica Universitária de Imunoalergologia. Faculdade de Medicina. Universidade de Lisboa. Lisboa.

DOI:

https://doi.org/10.20344/amp.11893

Keywords:

Angioedema, Angioedemas, Hereditary, Angiotensin-Converting Enzyme Inhibitors, Hospitalization

Abstract

Introduction: Hospitalizations due to angioedema are important especially in debilitating or life-threatening situations. The aim of this study was to evaluate the frequency and etiology of angioedema without urticaria in hospital admissions.
Material and Methods: The admissions between 2009 and 2013 in Centro Hospitalar Lisboa Norte with a diagnosis grouped under the ICD9 codes of angioedema were retrospectively analysed. The episodes of angioedema with urticaria were excluded. The admissions were categorized into 2 groups: A — hospitalizations motivated by the angioedema; B — hospitalizations in which the angioedema was an incidental finding.
Results: There were 169 hospitalizations (52% females, 96% adults, mean age 52 ± 20.8 years), distributed by 23 hospital departments, 51% in the Immunoallergology department. The mean annual angioedema admission rate was 72/100 000. In 68% of the cases, angioedema was the cause for the admission; in 32% an incidental finding. In 38% there was upper airway involvement. The etiologies were: hereditary angioedema in 24%, angiotensin converting enzyme inhibitor induced angioedema in 31%, idiopathic angioedema in 21%, thrombolysis induced angioedema in 13%, nonsteroidal anti-inflammatory drug-induced angioedema in 5%.
Discussion: The main etiology was angiotensin converting enzyme inhibitor angioedema, followed by hereditary angioedema and thrombolysis induced angioedema, and these findings concur with the international literature.
Conclusion: The mean annual angioedema admission rate was 72/100 000 and there was airway involvement in 38% of hospitalizations.

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Published

2019-11-04

How to Cite

1.
Cosme J, Spínola A, Ferreira MB, Barbosa MP. Hospitalizations due to Angioedema without Urticaria in a Portuguese Center: Five Year Retrospective Study. Acta Med Port [Internet]. 2019 Nov. 4 [cited 2023 Jun. 3];32(11):714-20. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/11893

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Original