Mucins and gastrointestinal malignancy. A new approach to the interpretation of biopsies.
DOI:
https://doi.org/10.20344/amp.1253Abstract
Mucous secretion in the gastrointestinal tract shows regional variations: neutral mucins predominate in the gastric mucosa, sialic acid-rich compounds in the small intestine and sulphated mucins in the large intestine; glycoprotein synthesis also varies with cell maturation from crypt to surface epithelium. Changes in these normal mucous patterns have been observed in carcinoma and particularly in the non-neoplastic adjacent mucosa: A) In the stomach extensive and severe intestinal metaplasia with increased sulphomucin secretion is often associated with carcinoma; B) In the small intestine alteration in the proportion of various sialic acids and the presence of sulphated material are found in areas adjacent to carcinoma; C) In the large intestine harbouring carcinoma sialomucins become predominant with decrease or absence of sulphated radicals. Alterations in glycoprotein synthesis have been implicated in malignancy and we believe that the changes described above may represent a feature of malignant transformation and thus be of value in the interpretation and possibly detection of early cancer.
Downloads
Downloads
How to Cite
Issue
Section
License
All the articles published in the AMP are open access and comply with the requirements of funding agencies or academic institutions. The AMP is governed by the terms of the Creative Commons ‘Attribution – Non-Commercial Use - (CC-BY-NC)’ license, regarding the use by third parties.
It is the author’s responsibility to obtain approval for the reproduction of figures, tables, etc. from other publications.
Upon acceptance of an article for publication, the authors will be asked to complete the ICMJE “Copyright Liability and Copyright Sharing Statement “(http://www.actamedicaportuguesa.com/info/AMP-NormasPublicacao.pdf) and the “Declaration of Potential Conflicts of Interest” (http:// www.icmje.org/conflicts-of-interest). An e-mail will be sent to the corresponding author to acknowledge receipt of the manuscript.
After publication, the authors are authorised to make their articles available in repositories of their institutions of origin, as long as they always mention where they were published and according to the Creative Commons license.
