Macular Cystoid Edema Induced by Nab-Paclitaxel

Authors

  • Sara Alves Pereira Departamento de Oftalmologia. Unidade Local de Saúde Matosinhos. Senhora da Hora.
  • Carolina Vale Departamento de Oftalmologia. Unidade Local de Saúde Matosinhos. Senhora da Hora.
  • Jorge Moreira Departamento de Oftalmologia. Unidade Local de Saúde Matosinhos. Senhora da Hora.
  • Filipa Sampaio Departamento de Oftalmologia. Unidade Local de Saúde Matosinhos. Senhora da Hora.

DOI:

https://doi.org/10.20344/amp.13421

Keywords:

Albumins/adverse effects, Albumin-Bound Paclitaxel/adverse effects, Macular Edema/chemically induced, Paclitaxel/adverse effects, Pancreatic Neoplasms/drug therapy

Abstract

A 61-year old male was referred to the Ophthalmology department because of decreased bilateral visual acuity. The patient had metastatic pancreatic adenocarcinoma and was being treated with gemcitabine+nab-paclitaxel. On examination, the patient presented best corrected visual acuities of 4/20 and 2/20 in the right and left eye, respectively. The optical coherence tomography revealed bilateral severe macular edema. Macular edema was considered secondary to nab-paclitaxel and the drug was discontinued. Three months after drug discontinuation, the patient presented best corrected visual acuities of 20/20 and 16/20 in the right and left eye, respectively, and normal fundoscopy. Macular edema is a very rare side effect of taxanes, and the etiopathology is still unknown. Edema is usually reversible upon discontinuation of the offending agent. Clinicians should be aware of this adverse effect of taxanes, and a high index of clinical suspicion is essential for diagnosis.

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Published

2022-04-01

How to Cite

1.
Alves Pereira S, Vale C, Moreira J, Sampaio F. Macular Cystoid Edema Induced by Nab-Paclitaxel. Acta Med Port [Internet]. 2022 Apr. 1 [cited 2024 Apr. 12];35(4):294-7. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/13421

Issue

Section

Case Report