Histioctic necrotizing lymphadenitis: (Kukuchi-Fujimoto disease): a diagnostic challenge.

Inês Antunes, Arturo Botella, Filipa Marques, Inês Araújo, Ana Abreu, Rosa Cardiga, Ana Leitão, Cândida Fonseca, Fátima Ceia


Kikuchi-Fujimoto disease, also called Histiocytic necrotizing lymphadentis, is a rare, benign and self-limited disease, with unknown etiology, that affects mainly young women, and is characterized by adenopathy (usually localized in the cervical region) and fever. Diagnosis is based on histopathological findings in ganglionar tissue obtained in excisional biopsy, which allows, in most cases, the differential diagnosis with other similar clinical conditions, but which have a completely different clinical evolution and therapeutic needs. We report a case of a twenty four year old woman with persistent cervical lymphadenopathy, in which histopathological examination followed by immunohistochemical analysis of ganglionar tissue revealed to be Kikuchi-Fujimoto disease.

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