Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 Vaccines

Authors

  • Jóni Costa Carvalho Allergy and Clinical Immunology Unit. Centro Hospitalar e Universitário de Coimbra. Coimbra. https://orcid.org/0000-0002-0444-7745
  • Francisca Cunha Allergy and Clinical Immunology Unit. Centro Hospitalar e Universitário de Coimbra. Coimbra.
  • Iolanda Alen Coutinho Allergy and Clinical Immunology Unit. Centro Hospitalar e Universitário de Coimbra. Coimbra. https://orcid.org/0000-0002-2511-4843
  • Carlos Loureiro Allergy and Clinical Immunology Unit. Centro Hospitalar e Universitário de Coimbra. Coimbra.
  • Emília Faria Allergy and Clinical Immunology Unit. Centro Hospitalar e Universitário de Coimbra. Coimbra.
  • Ana Todo Bom Allergy and Clinical Immunology Unit. Centro Hospitalar e Universitário de Coimbra. Coimbra. https://orcid.org/0000-0002-1850-6689

DOI:

https://doi.org/10.20344/amp.16096

Keywords:

Anaphylaxis, COVID-19 Vaccines, Hypersensitivity, SARS-CoV-2

Abstract

The first reports of hypersensitivity reactions following the rollout of COVID-19 vaccination programs have raised public concern. Given the recent availability and novel mechanisms of COVID-19 vaccines, there is limited data on possible hypersensitivity reactions. Although it seems rare, the incidence of anaphylaxis for approved COVID-19 vaccines has been suggested as being higher when compared to previous vaccines. Adequate risk assessment, recognition, classification, and management of hypersensitivity reactions is crucial to ensure safe immunization and avoid misinformation and vaccine hesitancy. In this review, we present an overview of the types of hypersensitivity reactions that can potentially occur due to vaccination and the possible allergenic components of COVID-19 vaccines, as well as a suggestion for causality and risk assessment for the BNT162b2, mRNA-1273 and AZD1222 vaccines.

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Published

2021-06-30

How to Cite

1.
Carvalho JC, Cunha F, Coutinho IA, Loureiro C, Faria E, Bom AT. Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 Vaccines. Acta Med Port [Internet]. 2021 Jun. 30 [cited 2023 Jan. 31];34(7-8):541-7. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/16096

Issue

Section

Review Articles