Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies

Authors

  • Cláudia Fidalgo Serviço de Patologia Clínica. Centro Hospitalar e Universitário de Coimbra. Coimbra. https://orcid.org/0000-0002-1640-4961
  • Alice Mendes Serviço de Patologia Clínica. Centro Hospitalar e Universitário de Coimbra. Coimbra.
  • Rosário Cunha Serviço de Patologia Clínica. Centro Hospitalar e Universitário de Coimbra. Coimbra.
  • Fernando Rodrigues Serviço de Patologia Clínica. Centro Hospitalar e Universitário de Coimbra. Coimbra.

DOI:

https://doi.org/10.20344/amp.16181

Keywords:

Autoimmune Diseases/chemically induced, Hydroxymethylglutaryl CoA Reductases, Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects, Muscular Diseases/chemically induced

Abstract

Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies. Although the diagnosis of myopathies relies on muscle biopsy, which is considered the gold-standard, the search for autoantibodies has proved to be an essential contribution to the diagnosis of immune-mediated myopathies. The detection of anti-HMGCR antibodies in the patient’s serum can be performed by enzyme immunoassays, and more recently, by imunofluorescence. As for the latter, the detection of anti-HMGCR antibodies is performed on tissue sections by indirect immunofluorescence and is characterized by a typical fluorescence pattern called “HMGCR Associated Liver IFL Pattern”. The authors present two case reports that show the importance of diagnosing statin-induced necrotizing myopathy as quickly as possible and the contribution of anti-HMGCR antibody detection for the diagnosis.

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Published

2022-07-01

How to Cite

1.
Fidalgo C, Mendes A, Cunha R, Rodrigues F. Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies. Acta Med Port [Internet]. 2022 Jul. 1 [cited 2024 Mar. 29];35(7-8):584-7. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/16181

Issue

Section

Case Report