Inflammation of BCG Inoculation Site Scar after the First Dose of an Anti-SARS-CoV-2 mRNA Vaccine

Authors

  • João Barros Rodrigues Serviço de Medicina Interna. Unidade Local de Saúde da Guarda. Guarda.
  • Maria Pacheco Serviço de Medicina Interna. Unidade Local de Saúde da Guarda. Guarda.
  • Ivan Antunes Serviço de Medicina Interna. Unidade Local de Saúde da Guarda. Guarda.
  • Ricardo Sousa Serviço de Medicina Geral e Familiar. Unidade de Saúde Familiar de Terras do Souza. Paredes.

DOI:

https://doi.org/10.20344/amp.16971

Keywords:

BCG Vaccine, Cicatrix, COVID-19 Vaccines, Drug-Related Side Effects and Adverse Reactions, mRNA Vaccines, SARS-CoV-2

Abstract

Inflammatory reactions in the Bacillus Calmette-Guérin (BCG) inoculation scar site have been previously described, in association with viral infections. The inflammation of the scar in association with other vaccines has been described with the flu vaccine and, more recently, after the second dose of mRNA anti-SARS-CoV-2 vaccines (mRNA-1273 e BNT162b2), in two healthcare workers. We present the case of a 27-year-old female, without a relevant past medical history, including no previous SARS-CoV-2 infection, and with inflammation of the BCG scar eight days after the first dose of the mRNA anti-SARS-CoV-2 vaccine. Pharmacovigilance and the notification of adverse events should be encouraged, as a way of warding off hesitation in this process.

Downloads

Download data is not yet available.

References

Garrido-García LM, Castillo-Moguel A, Vázquez-Rivera M, Cravioto P, Fernando G. Reaction of the BCG scar in the acute phase of Kawasaki disease in Mexican children. Pediatr Infect Dis J. 2017;36:e237-41.

Lopatynsky-Reyes EZ, Acosta-Lazo H, Ulloa-Gutierrez RM, Ávila-Aguero ML, Chacon-Cruz E. BCG scar local skin inflammation as a novel reaction following mRNA COVID-19 vaccines in two international healthcare workers. Cureus. 2021;13:e14453.

Chávarri-Guerra Y, Soto-Perez-de-Celis E. Erythema at the bacillus Calmette-Guerin scar after influenza vaccination. Rev Soc Bras Med Trop. 2019;53:e20190390.

Rezai MS, Shahmohammadi S. Erythema at BCG inoculation site in Kawasaki disease patients. Mater Sociomed. 2014;26:256-60.

Chavarri-Guerra Y, Soto-Perez-de-Celis E. Erythema at the bacillus Calmette-Guerin scar after influenza vaccination. Soc Bras Med Trop. 2019;53:e20190390.

Ritchie H, Mathieu E, Rodés-Guirao L, Appel C, Giattino C, Ortiz-Ospina E, et al. Coronavirus pandemic (COVID-19). [consultado 2022 jun 30]. Disponível em: https://ourworldindata.org/coronavirus.

Moorlag SJ, Taks E, Ten Doesschate T, van der Vaart TW, Janssen AB, Müller L, et al. Efficacy of BCG vaccination against respiratory tract infections in the elderly during the coronavirus disease 19 pandemic. Clin Infect Dis. 2022;75:e938-46.

Tao J, Rosenfeld D, Hsu J, Bhatia A. Reactivation of a BCG vaccination scar following the first dose of the Moderna COVID-19 vaccine. Cutis. 2022;109:148-9.

Published

2022-09-19

How to Cite

1.
Barros Rodrigues J, Pacheco M, Antunes I, Sousa R. Inflammation of BCG Inoculation Site Scar after the First Dose of an Anti-SARS-CoV-2 mRNA Vaccine. Acta Med Port [Internet]. 2022 Sep. 19 [cited 2024 Apr. 12];36(7-8):511-4. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/16971

Issue

Section

Case Report