Cutaneous Markers of Cardiovascular Diseases

Authors

  • Cláudia Brazão Serviço de Dermatovenereologia. Hospital de Santa Maria. Centro Hospitalar Universitário Lisboa Norte. Lisboa.
  • Rita Pimenta Serviço de Dermatovenereologia. Hospital Garcia de Orta. Almada.
  • Catarina Queirós Serviço de Dermatovenereologia. Hospital de Santa Maria. Centro Hospitalar Universitário Lisboa Norte. Lisboa.
  • Paulo Filipe Serviço de Dermatovenereologia. Hospital de Santa Maria. Centro Hospitalar Universitário Lisboa Norte. Lisboa.Clínica Universitária de Dermatovenereologia. Faculdade de Medicina. Universidade de Lisboa. Lisboa.
  • Luiz Menezes Falcão Serviço de Medicina Interna. Hospital de Santa Maria. Centro Hospitalar Universitário Lisboa Norte. Lisboa. Clínica Universitária de Medicina Interna. Faculdade de Medicina. Universidade de Lisboa. Lisboa.

DOI:

https://doi.org/10.20344/amp.18108

Keywords:

Cardiovascular Diseases, Skin Manifestations

Abstract

Cardiovascular diseases are one of the most important global medical challenges because of their high rates of morbidity and mortality. In this narrative review, the authors address the most important dermatologic signs that can be present in patients with cardiovascular disease. The early recognition of these underestimated entities is very important as it may lead to an early diagnosis and timely treatment, thus lessening the effects of long-term disease and possibly improving the prognosis.

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References

Dahlöf B. Cardiovascular disease risk factors: epidemiology and risk assessment. Am J Cardiol. 2010;105:3A-9.

Saksena F. Local and systemic manifestations of cardiovascular disease. In: Ranganattan NSivaciyan V, Saksena F, editors. The art and science of cardiac physical examination. New Jersey: Humana Press; 2007. p.361-95.

Uliasz A, Lebwohl M. Cutaneous manifestations of cardiovascular diseases. Clin Dermatol. 2008;26:243-54.

Mcdonnell JK. Cardiac disease and the skin. Dermatol Clin. 2002;20:503-11.

Chan HL. Cutaneous manifestations of cardiac diseases. Singapore Med J. 1990;31:480-85.

Trayes KP, Studdiford JS. Edema: diagnosis and management. Am Fam Physician. 2013;88:102-10.

O’Gara PT, Loscalzo J. Physical examination of the cardiovascular system. In: Jameson JL, Kasper DL, Longo DL, Fauci AS, Hauser SL, Loscalzo J, editors. Harrison’s principles of Internal Medicine. 20th ed. New York: McGraw-Hill; 2018 p.1666-75.

Inamdar A, Inamdar A. Heart failure: diagnosis, management and utilization. J Clin Med. 2016;5:62.

Stone J, Hangge P, Albadawi H, Wallace A, Shamoun F, Knuttien M, et al. Deep vein thrombosis: pathogenesis, diagnosis, and medical management. Cardiovasc Diagn Ther. 2017;7:S277-84.

O’Gara PT, Loscalzo J. Hypoxia and cyanosis. In: Jameson JL, Kasper DL, Longo DL, Fauci AS, Hauser SL, Loscalzo J, editors. Harrison’s principles of Internal Medicine. 20th ed. New York: McGraw-Hill; 2018.p.234-7.

Spicknall KE, Zirwas MJ, English JC. Clubbing: an update on diagnosis, differential diagnosis, pathophysiology, and clinical relevance. J Am Acad Dermatol. 2005;52:1020-8.

Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 2019;234:1-12.

Dwivedi S. Cutaneous markers of coronary artery disease. World J Cardiol. 2010;2:262.

Wagner Jr RF, Wagner KD. Cutaneous signs of coronary artery disease. Int J Dermatol. 1983;22:215-20.

Schwarzenberger K, Callen J. Dermatologic manifestations in patients with systemic disease. In: Bolognia JL, Schaffer JV, Cerroni L, editors. Dermatology. 4th ed. Amsterdam: Elsevier; 2018:819-43.

Forrestel A, Micheletti R. Skin manifestations of internal organ disorders. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, Michael AJ, et al, editors. Fitzpatrick’s dermatology. 9th ed. New York: McGraw-Hill; 2019:2425-40.

Davis TM, Stuccio G, Balme M, Bruce DG, Jackson D. The diagonal ear lobe crease (Frank’s sign) is not associated with coronary artery disease or retinopathy in type 2 diabetes: the Frernantle Diabetes Study. Aust N Z J Med. 2000;30:573-7.

Frank ST. Aural sign of coronary artery disease. N Engl J Med. 1973;289:327-8.

Shoenfeld Y, Mor R, Weinberger A, Pinkhas J. Diagonal ear lobe crease and coronary risk factors. J Am Geriatr Soc. 1980;28:184-7.

Sanches MM, Roda Â, Pimenta R, Filipe PL, Freitas JP. Cutaneous manifestations of diabetes mellitus and prediabetes. Acta Med Port. 2019;32:459-65.

Carabello BA. Modern management of mitral stenosis. Circulation. 2005;112:432-7.

Akinseye OA, Pathak A, Ibebuogu UN. Aortic valve regurgitation: a comprehensive review. Curr Probl Cardiol. 2018;43:315-34.

Iung B, Duval X. Infective endocarditis: innovations in the management of an old disease. Nat Rev Cardiol. 2019;16:623-35.

Servy A, Valeyrie-Allanore L, Alla F, Lechiche C, Nazeyrollas P, Chidiac C, et al. Prognostic value of skin manifestations of infective endocarditis. JAMA Dermatol. 2014;150:494-500.

Gunson TH, Oliver GF. Osler’s nodes and Janeway lesions. Australas J Dermatol. 2007;48:251-5.

Pepe G, Giusti B, Sticchi E, Abbate R, Gensini GF, Nistri S. Marfan syndrome: current perspectives. Appl Clin Genet. 2016;9:55-65.

Pyeritz RE. The Marfan syndrome. Annu Rev Med. 2000;51:481-510. 28. Sulli A, Talarico R, Scirè CA, Avcin T, Castori M, Ferraris A, et al. Ehlers-Danlos syndromes: state of the art on clinical practice guidelines. RMD Open. 2018;4:1-6.

Beighton P. The dominant and recessive forms of cutis laxa. J Med Genet. 1972;9:216-21.

Mohamed M, Voet M, Gardeitchik T, Morava E. Cutis laxa. Adv Exp Med Biol. 2014;802:161-84.

Stumpf MJ, Schahab N, Nickenig G, Skowasch D, Schaefer CA. Therapy of pseudoxanthoma elasticum: current knowledge and future perspectives. Biomedicines. 2021;9:1895.

Denayer E, Legius E. What’s new in the neuro-cardio-facial-cutaneous syndromes? Eur J Pediatr. 2007;166:1091-8.

Sundaresan S, Migden MR, Silapunt S. Stasis dermatitis: pathophysiology, evaluation, and management. Am J Clin Dermatol. 2017;18:383-90.

Nicholls SC. Sequelae of untreated venous insufficiency. Semin Intervent Radiol. 2005;22:162-8.

Santler B, Goerge T. Chronic venous insufficiency – a review of pathophysiology, diagnosis, and treatment. J Dtsch Dermatol Ges. 2017;15:538-56.

Herouy Y, Mellios P, Bandemir E, Dichmann S, Nockowski P, Schopf E, et al. Inflammation in stasis dermatitis upregulates MMP-1, MMP-2 and MMP-13 expression. J Dermatol Sci. 2001;25:198-205.

Weaver J, Billings SD. Initial presentation of stasis dermatitis mimicking solitary lesions: a previously unrecognized clinical scenario. J Am Acad Dermatol. 2009;61:1028-32.

Francès C, Niang S, Laffitte E, le Pelletier F, Costedoat N, Piette JC. Dermatologic manifestations of the antiphospholipid syndrome: two hundred consecutive cases. Arthritis Rheum. 2005;52:1785-93.

Schreiber K, Sciascia S, de Groot PG, Devreese K, Jacobsen S, Ruiz-Irastorza G, et al. Antiphospholipid syndrome. Nat Rev Dis Primers. 2018;4.

Pinto-Almeida T, Caetano M, Sanches M, Selores M. Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and management. Acta Reumatol Port. 2013;32:10-8.

Carapetis JR, Beaton A, Cunningham MW, Guilherme L, Karthikeyan G, Mayosi BM, et al. Acute rheumatic fever and rheumatic heart disease. Nat Rev Dis Primers. 2016;2:1-24.

Cunningham MW. Molecular mimicry, autoimmunity, and infection: the cross-reactive antigens of group a streptococci and their sequelae. Microbiol Spectr. 2019;7:10.1128/microbiolspec.GPP3-0045-2018.

Gewitz MH, Baltimore RS, Tani LY, Sable CA, Shulman ST, Carapetis J, et al. Revision of the Jones criteria for the diagnosis of acute rheumatic fever in the era of Doppler echocardiography a scientific statement from the American heart association. Circulation. 2015;131:1806-18.

Ghanem KG, Ram S, Rice PA. The modern epidemic of syphilis. N Engl J Med. 2020;382:845-54.

Lukehart S. Syphilis. In: Jameson JL, Kasper DL, Longo DL, Fauci AS, Hauser SL, Loscalzo J, editors. Harrison’s principles of Internal Medicine. 20th ed. New York: McGraw-Hill; 2018. p.1279-86.

Kreps A, Paltoo K, McFarlane I. Cardiac manifestations in systemic lupus erythematosus: a case report and review of the literature. Am J Med Case Rep. 2018;6:180-3.

Jarrett P, Werth VP. A review of cutaneous lupus erythematosus: improving outcomes with a multidisciplinary approach. J Multidiscip

Healthc. 2019;12:419-28.

Jain D, Halushka MK. Cardiac pathology of systemic lupus erythematosus. J Clin Pathol. 2009;62:584-92.

Dietz SM, van Stijn D, Burgner D, Levin M, Kuipers IM, Hutten BA, et al. Dissecting Kawasaki disease: a state-of-the-art review. Eur J Pediatr. 2017;176:995-1009.

Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 2004;110:2743-71.

Denton CP, Khanna D. Systemic sclerosis. Lancet. 2017;390:1685-99.

Bargagli E, Prasse A. Sarcoidosis: a review for the internist. Intern Emerg Med. 2018;13:325-31.

Katta R. Cutaneous sarcoidosis: a dermatologic masquerader. Am Fam Physician. 2002;5:1581-4.

DeWane ME, Waldman R, Lu J. Dermatomyositis: clinical features and pathogenesis. J Am Acad Dermatol. 2020;82:267-81.

Waldman R, DeWane ME, Lu J. Dermatomyositis: diagnosis and treatment. J Am Acad Dermatol. 2020;82:283-96.

Hruza LL, Hruza GJ. Saphenous vein graft donor site dermatitis case reports and literature review. Arch Dermatol. 1993;129:609-12.

Frishman WH, Brosnan BD, Grossman M, Dasgupta D, Sun DK. Adverse dermatologic effects of cardiovascular drug therapy: part I. Cardiol Rev. 2002;10:230-46.

Frishman WH, Brosnan BD, Grossman M, Dasgupta D, Sun DK. Adverse dermatologic effects of cardiovascular drug therapy: part II. Cardiol Rev. 2002;10:285-300.

Frishman WH, Brosnan BD, Grossman M, Dasgupta D, Sun DK. Adverse dermatologic effects of cardiovascular drug therapy: part III. Cardiol Rev. 2002;10:337-48.

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Published

2022-06-20

How to Cite

1.
Brazão C, Pimenta R, Queirós C, Filipe P, Menezes Falcão L. Cutaneous Markers of Cardiovascular Diseases. Acta Med Port [Internet]. 2022 Jun. 20 [cited 2024 Nov. 12];35(12):899-907. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/18108

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Review Articles