Acute lymphoblastic leukemia in childhood. A 10-year experience with the DFCI 81-01 protocol.

Authors

  • A F de Lacerda Serviço de Pediatria, Instituto Português de Oncologia de Francisco Gentil, Lisboa.
  • M Chagas
  • A Neto
  • E Vieira
  • M J Ribeiro
  • F Pereira
  • A Ambrósio
  • M Sousinha

DOI:

https://doi.org/10.20344/amp.2154

Abstract

Acute lymphoblastic leukemia is the most frequently encountered pediatric cancer. Approximately 70% of cases can be cured of the disease. In this article, we describe the experience of our Center in the last ten years with a treatment protocol adapted from protocol DFCI 81-01 (from the Dana Farber Cancer Institute, Boston). We conclude that it is easily accomplished, well tolerated and that it allowed us to significantly improve the outcome of our patients (80% 5 year-survival). Nevertheless, we are currently in the process of changing to a new protocol--one that will hopefully achieve a comparable cure rate with less long-term toxicity.

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How to Cite

1.
de Lacerda AF, Chagas M, Neto A, Vieira E, Ribeiro MJ, Pereira F, Ambrósio A, Sousinha M. Acute lymphoblastic leukemia in childhood. A 10-year experience with the DFCI 81-01 protocol. Acta Med Port [Internet]. 1999 Nov. 30 [cited 2024 Nov. 13];12(7-11):287-92. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/2154

Issue

Section

Arquivo Histórico