Valproate in Psychiatric Practice: Risks to Fertility and Future Generations

Margarida Alves; Diana Durães; Cátia Santos

doi:10.20344/amp.22284

Valproate in Psychiatric Practice: Risks to Fertility and Future Generations

Authors

Margarida Alves Department of Psychiatry and Mental Health. Centro Hospitalar de Setúbal. Setúbal.
Diana Durães Department of Psychiatry and Mental Health. Centro Hospitalar de Setúbal. Setúbal.
Cátia Santos Department of Psychiatry and Mental Health. Centro Hospitalar de Setúbal. Setúbal.

DOI:

https://doi.org/10.20344/amp.22284

Keywords:

Fertility/drug effects, Mental Disorders/drug therapy, Valproic Acid/adverse effects

Abstract

N/A

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References

Owens DC. Sodium valproate in psychiatric practice: time for a change in perception. Br J Psychiatry. 2019;215:516-8.

Angus-Leppan H, Arkell R, Watkins L, Heaney D, Cooper P, Shankar R. New valproate regulations, informed choice and seizure risk. J Neurol. 2024;271:5671-86.

Coste J, Blotiere PO, Miranda S, Mikaeloff Y, Peyre H, Ramus F, et al. Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France. Sci Rep. 2020;10:17362.

Tallon E, O’Donovan L, Delanty N. Reversible male infertility with valproate use: a review of the literature. Epilepsy Behav Rep. 2021;16:100446.

Medicines and Healthcare Products Regulatory Agency. Valproate: review of safety data and expert advice on management of risks. 2023. [cited 2024 Nov 19]. Available from: https://assets.publishing.service.gov.uk/media/65660310312f400013e5d508/Valproate-report-reviewand-expert-advice.pdf.

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Published

2025-01-02

How to Cite

Alves M, Durães D, Santos C. Valproate in Psychiatric Practice: Risks to Fertility and Future Generations. Acta Med Port [Internet]. 2025 Jan. 2 [cited 2025 Jan. 7];38(1):56-7. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/22284

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Issue

Vol. 38 No. 1 (2025): January

Section

Letters to the Editor

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