Pediatric Leydig Cell Tumor: Biochemical Mimicry of Adrenal Disease and a Cause of Central Precocious Puberty

Marta Isabel Dias; Rita Silva Pereira; Ana Miguel Simões; Ana Rita Batista; Vânia Martins

doi:10.20344/amp.24921

Pediatric Leydig Cell Tumor: Biochemical Mimicry of Adrenal Disease and a Cause of Central Precocious Puberty

Authors

Marta Isabel Dias Department of Pediatrics. Unidade Local de Saúde Trás-os-Montes e Alto Douro. Vila Real. https://orcid.org/0009-0007-9937-3040
Rita Silva Pereira Department of Pediatrics. Unidade Local de Saúde Trás-os-Montes e Alto Douro. Vila Real. https://orcid.org/0009-0000-9916-669X
Ana Miguel Simões Department of Radiology. Unidade Local de Saúde Trás-os-Montes e Alto Douro. Vila Real. https://orcid.org/0009-0007-1393-4039
Ana Rita Batista Department of Pediatrics. Unidade Local de Saúde Trás-os-Montes e Alto Douro. Vila Real. https://orcid.org/0009-0005-6091-1599
Vânia Martins Department of Pediatrics. Unidade Local de Saúde Trás-os-Montes e Alto Douro. Vila Real. https://orcid.org/0000-0002-4399-2666

DOI:

https://doi.org/10.20344/amp.24921

Keywords:

Child, Leydig Cell Tumor, Puberty, Precocious, Testicular Neoplasms

Abstract

n/a.

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References

Atqiaee K, Mohammadi Tofigh A, Salehpour S, Mirshemirani A. Leydig cell tumor in children: a case report and literature review. Transl Res Urol. 2020;2:32-6.

Paffenholz P. Kindliche Hodentumoren. Urologie. 2025;64660–3.

Solish SB, Goldsmith MA, Voutilainen R, Miller WL. Molecular characterization of a Leydig cell tumor presenting as congenital adrenal hyperplasia. J Clin Endocrinol Metab. 1989;69:1148–52.

Grand T, Hermann AL, Gérard M, Arama E, Ouerd L, Garrouche N, et al. Precocious puberty related to Leydig cell testicular tumor: the diagnostic imaging keys. Eur J Med Res. 2022;27:67.

Verrotti A, Penta L, Zenzeri L, Lucchetti L, Giovenali P, De Feo P. True precocious puberty following treatment of a leydig cell tumor: two case reports and literature review. Front Pediatr. 2015;3:93.

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Published

2026-09-01

How to Cite

Dias MI, Silva Pereira R, Simões AM, Batista AR, Martins V. Pediatric Leydig Cell Tumor: Biochemical Mimicry of Adrenal Disease and a Cause of Central Precocious Puberty. Acta Med Port [Internet]. 2026 Sep. 1 [cited 2026 Sep. 2];39(9):591-2. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/24921

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Issue

Vol. 39 No. 9 (2026): September

Section

Letters to the Editor

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