Homocysteinemia as a risk factor in early cerebrovascular disease.

Authors

  • R P Reis Serviço de Medicina, Hospital S. Francisco Xavier, Lisboa.
  • J Azinheira
  • H P Reis
  • M Pereira
  • A Baptista
  • M Crespo
  • J E Pina
  • N C Ferreira
  • A S Luís

DOI:

https://doi.org/10.20344/amp.2899

Abstract

To determine whether hyperhomocysteinemia represents a risk factor of early thrombotic cerebrovascular disease.In a group of patients under 55 years of age (n = 33, 19 males) which had suffered a stroke from 3 months to 1 year before the study, defined by clinical criteria and presence of cerebral infarction confirmed by tomography, without history or predisposition to embolic disease. The patients were matched with a group of normal controls of checkup program, in terms of age, and sex. Patients and controls with a history of alcoholism, clinical or laboratory signs of renal or hepatic insufficiency or with a history of recent ingestion of Group B vitamins were excluded since these conditions would influence homocysteinemia levels. We measured the plasmatic basal homocysteinemia of patients and controls (HC) and 6 hours later a methionine overload of 0.1 g/Kg body weight (LOAD HC).Patients; Controls; Signific.; Age 46.0 +/- 7.7; 45.9 +/- 7.8; NS; Basal HC. 10.1 +/- 3.4; 8.5 +/- 1.7; p < 0.05; Load HC 28.0 +/- 7.6; 22.7 +/- 5.5; p < 0.01.In this study hyperhomocysteinemia appears as a risk factor for thrombotic cerebrovascular disease before the age of 55;-The measurement of homocysteinemia after the methionine loading test was more discriminative than the basal measurement;-A larger number of patients and controls will be necessary to establish the relative importance of homocysteinemia among other vascular risk factors in cerebrovascular disease.

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How to Cite

1.
Reis RP, Azinheira J, Reis HP, Pereira M, Baptista A, Crespo M, Pina JE, Ferreira NC, Luís AS. Homocysteinemia as a risk factor in early cerebrovascular disease. Acta Med Port [Internet]. 1994 May 30 [cited 2024 Mar. 29];7(5):285-9. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/2899

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Section

Arquivo Histórico