New insights in adult Still disease's knowledge.

Authors

  • Nuno Cabanelas Serviço de Medicina, Hospital Distrital de Santarém, Portugal.
  • Patrícia Ferreira
  • Maria Cristina Esteves
  • Fausto Roxo

DOI:

https://doi.org/10.20344/amp.328

Abstract

Adult Still's Disease has systemic consequences, an inflammatory origin and unknown etiology. Knowledge about this disease is still limited, but some evolution has occurred in the last few years.Using a clinical case as example, the purpose of this paper is to review actual knowledge about Adult Still's Disease, giving special relevance to the most recent findings.Search in Pubmed and Cochrane database (1970-2009) for the terms Adultonset Still's Disease for all available papers. Those considered clinically and historically relevant were selected. An additional search was done in scientific journals and textbooks and other web sites. The information was analysed, using a clinical case in an atypical age as illustration.Adult Still's Disease as multiple manifestations, being fever, evanescent skin rash and arthralgia the most typical. Laboratorial parameters are inespecific, but high glycosilated ferritin is highly suggestive. Non-steroid anti-inflammatory, corticoids, immunosuppressors, and recent biological agents are used in treatment.Being uncommon, actual knowledge about this disease is based in isolated descriptions or very short series. There are no specific guidelines, but diagnostic criteria have been improved in recent years, as have the insights in pathophysiology and therapeutic resources.

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Published

2011-02-28

How to Cite

1.
Cabanelas N, Ferreira P, Esteves MC, Roxo F. New insights in adult Still disease’s knowledge. Acta Med Port [Internet]. 2011 Feb. 28 [cited 2024 Nov. 13];24(1):183-92. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/328

Issue

Section

Arquivo Histórico