Cytomegalovirus infection in kidney transplantation.

Authors

  • A Sousa Unidade de Transplantação Renal da Cruz Vermelha Portuguesa, Lisboa.
  • M M Magalhães
  • M J Sampaio
  • A M Correia
  • A G da Costa
  • E J Pena

DOI:

https://doi.org/10.20344/amp.3371

Abstract

150 patients, subjected to kidney graft transplantation between January 1988 and December 1989, were studied. Mean +/- 95% CL age was 37.5 +/- 2.03 (range 12-69) years. IgG and IgM antibodies levels (ELISA) cytomegalovirus (CMV) were investigated in the donor before organ harvesting and in the kidney recipients on 1st and 21th days and then on the 3rd, 6th and 9th months after transplantation. Patients lacking either donor or 1st day studies were excluded. 133 donor (D) receptor (R) pairs were classified as group 1) D+/R+, 2) D+/R-, 3) D-/R+ e 4) D-/R-. Prevalence, severity of CMV disease and date of diagnosis were studied. Mean time +/- 95% CI of diagnosis after transplantation was 78.4 +/- 15.1 days. Seronegative receptors had a statistically significant higher prevalence of the disease as to seropositive receptors, but not a higher incidence of disease severity. One out of five patients had a serious form of disease. Hiperimmune globulin was used in 15 patients (all serious forms and 3 moderate forms of of disease). No patient died as a result of CMV infection.

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How to Cite

1.
Sousa A, Magalhães MM, Sampaio MJ, Correia AM, da Costa AG, Pena EJ. Cytomegalovirus infection in kidney transplantation. Acta Med Port [Internet]. 1991 Oct. 30 [cited 2024 Nov. 22];4(5):231-5. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/3371

Issue

Vol. 4 No. 5 (1991): Setembro-Outubro

Section

Arquivo Histórico

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