Etiopathogeny of Parkinson disease. The MPTP revolution.
DOI:
https://doi.org/10.20344/amp.3575Abstract
Faz-se a apresentação do modelo experimental da doença de Parkinson, desenvolvido a partir do momentoem que se constatou que um derivado sintético da heroína — o MPTP — provoca nos humanos, um quadro semelhante ao da doença idiopática.Discute-se o mecanismo de acção do MPTP e as implicações que este fenómeno tem no processo da descoberta de um factor etiológico para a doença de Parkinson. Finalmente discutem-se as perspectivas terapêuticas abertas pela exploração do modelo experimental do MPTP.Downloads
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