Effects of irradiated glucose solutions on DMBA-induced tumors in rats.

Authors

  • António M. Baptista Laboratório de Isótopos. Centro de Medicina Nuclear (INIC). Instituto Português de Oncologia de Francisco Gentil. Lisboa. Portugal.
  • Richard M. Roppel Department of Biomechanics. Michigan. State University. East Lansing. Michigan. USA.

DOI:

https://doi.org/10.20344/amp.3881

Abstract

This is a study of the effects of irradiated glucose-saline solutions (60Co, 105 R at a dose rate of 1.7 X 106 R/h) on tumors induced by the intravenous injection of dimethylbenzanthracene (DMBA) in female Sprague-Dawley rats. Each animal received 10 cc intraperitoneal injections of the irradiated solution spaced over 17 days. As a control two groups of tumor bearing animals were used: one received irradiated isotonic saline solution, and the other unirradiated glucose-saline solution. It could be concluded that those animals which received the irradiated glucose-saline solution experienced retardation of the tumor disease both during and after the treatment period relative to the other groups under study. The results suggest that radiolysis of hexoses can give rise to a carcinostatic compound relatively non-toxic toward non-dividing cells.

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How to Cite

1.
Baptista AM, Roppel RM. Effects of irradiated glucose solutions on DMBA-induced tumors in rats. Acta Med Port [Internet]. 1981 Apr. 30 [cited 2024 Dec. 27];3(2):125-32. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/3881

Issue

Vol. 3 No. 2 (1981): Março-Abril

Section

Arquivo Histórico

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