Immunologic profile of HIV-2 seropositive African individuals (follow-up).

Authors

  • A S Pinto Instituto de Higiene e Medicina Tropical, Laboratório de Imunologia, I.P.O.F.G., Lisboa.
  • W F Ferreira
  • C Costa
  • A P Silva
  • E P Alvarez
  • R A Sousa
  • K Mansinho
  • J L Champalimaud
  • C Araújo
  • F Dias

DOI:

https://doi.org/10.20344/amp.4475

Abstract

In the geographic distribution of HIV-2, it is known that this infection is most prevalent in West Africa. Since 1986 we have studied seropositive and seronegative clusters, in Guinea-Bissau with follow-ups in 1988, 1989, 1990 and 1991. Analysis of the results show the high incidence of this infection. 8.51% of the 4,372 people of the general population studied were seropositive, showing the high predominance of HIV-2 infection. Only 4 cases were exclusively reactive to HIV-1 and a slow evolution of HIV-1 infections. In the seroconversions of HIV-2 infections the antibodies appeared first to the core components and secondly to the surface glycoproteins. Some of the laboratory parameters affected in the evolution of the infection include a gradual increase in immunoglobulins and a decrease in CD4 lymphocytes and in the CD4/CD8 ratio. A comparison of these variations in HIV-2 infected people, with or without cross-reactivity to HIV-1, reveals that they are much more evident in exclusively HIV-2 positive people. This fact can indicate that the variants responsible for the cross-reactions are less pathogenic and phylogenetically less developed.

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How to Cite

1.
Pinto AS, Ferreira WF, Costa C, Silva AP, Alvarez EP, Sousa RA, Mansinho K, Champalimaud JL, Araújo C, Dias F. Immunologic profile of HIV-2 seropositive African individuals (follow-up). Acta Med Port [Internet]. 1991 Dec. 31 [cited 2024 Nov. 23];4:64S-6. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/4475

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Section

Arquivo Histórico