Chronic benign neutropenia of childhood.

Authors

  • Ana Paula Azevedo Serviço de Patologia Clínica, Hospital de São Francisco Xavier, Lisboa.
  • Cristina Gamelas
  • Valdemar Teixeira
  • Marta Contreiras
  • Rita Monteiro
  • Maria Gorete Vale
  • Fernando Durães

DOI:

https://doi.org/10.20344/amp.624

Abstract

The term neutropenia concerns the reduction of the amount of circulating neutrophils in peripheric blood. The Chronic Benign Neutropenia of Childhood (CBNC) is characterized by the presence of a circulating neutrophils total number (absolute count) below 1,5 x 10(9)L, for over a six-month period. The diagnosis is established when the laboratorial changes occur during the first two years of life, without previous history of serious infections, nor neutrophils morphological changes, nor hypocellular bone marrow examination. The cellularity is normal or increased and a neutrophil maturation arrest at some phase can be observed. Generally, the whole process is solved by the age of four. Because this is a very rare clinical situation, it justifies a bibliographic revision about the theme. We present the clinical case of a 15 month-old-child, admitted with fever and diarrhea associated with neutropenia. Bone marrow aspiration, other laboratorial exams carried out during hospital internment and presented clinical evolution were consistent with CBNC diagnosis.

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How to Cite

1.
Azevedo AP, Gamelas C, Teixeira V, Contreiras M, Monteiro R, Vale MG, Durães F. Chronic benign neutropenia of childhood. Acta Med Port [Internet]. 2010 Jun. 14 [cited 2024 Nov. 4];23(3):521-6. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/624

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Section

Arquivo Histórico