Warfarin hipersensitivity: how to deal with it?.

Authors

  • Ana Furtado Lima Serviço de Medicina Materno-Fetal, Maternidade Dr. Alfredo da Costa, Lisboa.
  • José Reis
  • Fátima Serrano
  • Augusta Borges

DOI:

https://doi.org/10.20344/amp.678

Abstract

The authors report a clinical case of warfarin hypersensitivity noticed when a patient, with thromboembolic risk, was submitted to warfarin. She was found to be heterozigotic to -1639G>A (gene VKORC1) and homozygotic to 1075A>C (genotype CYP2C9*3/*3). In this article the warfarin pharmacodinamics and its role over Vitamin K is revisited. It includes some suggested indications for investigating genetic polymorphisms, in order to avoid complications associated with warfarin.

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How to Cite

1.
Lima AF, Reis J, Serrano F, Borges A. Warfarin hipersensitivity: how to deal with it?. Acta Med Port [Internet]. 2010 Jul. 30 [cited 2024 Nov. 23];23(4):727-30. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/678

Issue

Section

Arquivo Histórico