Leiomyosarcoma of the Inferior Vena Cava: A Case Report of Complete and Sustained Response with Trabectedin

Authors

  • André Cruz Serviço de Medicina Interna. Centro Hospitalar do Algarve. Faro.
  • Luís Bretes Serviço de Medicina Interna. Centro Hospitalar do Algarve. Faro. Unidade de Oncologia Médica. Centro Hospitalar do Algarve. Faro.
  • Carlos Reis Serviço de Medicina Interna. Centro Hospitalar do Algarve. Faro. Unidade de Oncologia Médica. Centro Hospitalar do Algarve. Faro.
  • Irene Furtado Serviço de Medicina Interna. Centro Hospitalar do Algarve. Faro. Unidade de Oncologia Médica. Centro Hospitalar do Algarve. Faro.

DOI:

https://doi.org/10.20344/amp.7211

Keywords:

Disease-Free Survival, Leiomyosarcoma, Vena Cava, Inferior, Trabectedin.

Abstract

Inferior vena cava leiomyosarcoma is a very rare tumor, accounting for only 0.5% of all soft tissue sarcomas. As the other leyomiosarcomas of vascular origin, they have a poor prognosis, and radical resection with surgical margins free of tumor is the only potentially curative treatment. We present a case of a 46 year-old woman with metastatic inferior vena cava leiomyosarcoma who progressed after anthracyclines and ifosfamide and achieved a complete and sustained response with trabectedin. Beyond progression, the patient started third line treatment with pazopanib. A brief review of literature is also given. This case supports the efectiveness of a recent therapeutic agent, with an impressive progression-free survival in a recurrent metastatic inferior vena cava leiomyosarcoma.

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Published

2016-04-29

How to Cite

1.
Cruz A, Bretes L, Reis C, Furtado I. Leiomyosarcoma of the Inferior Vena Cava: A Case Report of Complete and Sustained Response with Trabectedin. Acta Med Port [Internet]. 2016 Apr. 29 [cited 2024 Mar. 28];29(4):284-6. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/7211

Issue

Section

Case Report