Surgical treatment of primary hyperparathyroidism with intraoperative iPTH determination.

Authors

  • Miguel Allen Serviço de Cirurgia II, Hospital de Egas Moniz, Lisboa.
  • Isabel Almeida
  • Joaquim Torrinha

DOI:

https://doi.org/10.20344/amp.763

Abstract

Primary hyperparathyroidism (pHPT) is most frequently caused by a solitary adenoma. Surgical intervention has a high cure rate, particularly when associated with a fast intraoperative intact parathyroid hormone (IOPTH) assay. Aim: to evaluate the performance and accuracy when applying this technique.we conducted a retrospective study of the last 20 patients with pHPT (mean age 59, range 24-75) that had a surgical intervention in our unit. IOPTH was used in 14 patients, with dosage at 5, 10, 15 and 30 minutes after removal of the adenoma.The localization exams had a sensitivity of >75%. The surgical procedure of choice was a unilateral dissection through a 4cm central mini-incision, with all patients experiencing a reduction of >50% of the IOPTH at 10 minutes. There were no surgical complications and the average length of the follow-up period was 11.4 months. The mean calcemia and iPTH dosage progression, from pre-surgery to the last follow-up visit, was respectively of 11 (SD1) to 9.4 (SD0.5) mg/dl and of 233.3 (SD177.5) to 57.1 (SD42) pg/ml. Symptoms improved in all patients.

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How to Cite

1.
Allen M, Almeida I, Torrinha J. Surgical treatment of primary hyperparathyroidism with intraoperative iPTH determination. Acta Med Port [Internet]. 2008 Apr. 18 [cited 2024 Mar. 29];21(1):49-54. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/763

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Section

Arquivo Histórico