Diagnostic and Therapeutic Approach of Chronic Spontaneous Urticaria: Recommendations in Portugal

Authors

  • Célia Costa Serviço de Imunoalergologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Portugal. Clínica Universitária de Imunoalergologia. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.
  • Margarida Gonçalo Serviço de Dermatologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal. Clínica de Dermatologia. Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.
  • On behalf of GPEU – Grupo Português de Estudos de Urticária

DOI:

https://doi.org/10.20344/amp.8294

Keywords:

Chronic Disease, Histamine H1 Antagonists, Omalizumab, Practice Guidelines, Urticaria/diagnosis, Urticaria/therapy.

Abstract

Chronic spontaneous urticaria is a complex disorder, of unclear etiology, easily diagnosed although often difficult to treat. It has a significant impact on the patients’ quality of life and results in high direct and indirect costs. The diagnosis of chronic spontaneous urticaria is mainly clinical and a limited number of tests is recommended for differential diagnosis and/or for the investigation/exclusion of possible causes. In addition to the complete blood count and C-reactive protein, and/or erythrocyte sedimentation rate, additional tests must be selected according to clinical criteria. The aim of therapy is the complete clinical control of chronic spontaneous urticaria. Evolution should be documented by weekly symptom scoring – Weekly Urticaria Activity Score (UAS7) –, as well as the assessment of quality of life. The therapeutic approach is based on second-generation H1 antihistamines (anti-H1) administered continuously in the approved doses (first line), and, in the absence of a clinical response, up to four times the daily-approved dose (second line). First generation H1 antihistamines are not recommended. Approximately 30% of patients are not controlled with second line therapy, and it is recommended to add a third line therapy. Of the two options, omalizumab and cyclosporine, only omalizumab is approved for chronic spontaneous urticaria and has a better safety profile, thus being preferably recommended. In Portugal there are no national-based recommendations applicable to clinical practice. The elaboration of these recommendations is justified by the need to standardize both the diagnosis and the treatment approach of patients with chronic spontaneous urticaria in Portugal, and for the referral of patients to specialized centers, in the most severe cases.

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Published

2016-11-30

How to Cite

1.
Costa C, Gonçalo M, GPEU – Grupo Português de Estudos de Urticária O behalf of. Diagnostic and Therapeutic Approach of Chronic Spontaneous Urticaria: Recommendations in Portugal. Acta Med Port [Internet]. 2016 Nov. 30 [cited 2024 Nov. 21];29(11):763-81. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/8294

Issue

Section

Guidelines