Diabetic nephropathy: glomerular filtration rate and estimated creatinine clearance.

Joana Guimarães, Margarida Bastos, Miguel Melo, Manuela Carvalheiro

Abstract


To assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR).We analysed the GFR measure by Tc99m-DTPA method and the estimated by the Cockroft Gault formula, in 21 subjects with type 1 or type 2 diabetes.There was a strong positive correlation between the two methods but the Cockroft Gault formula underestimated the GFR.The formula gives a accurate estimates of GFR, when GFR is <100 ml/min/1,73 m2. Beside the underestimation, the formula could be used in the management of diabetic nephropathy because the repeated isotope assessments of renal function are impracticable.

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