Diabetic nephropathy: glomerular filtration rate and estimated creatinine clearance.

Authors

  • Joana Guimarães Serviço Endocrinologia, Diabetes e Metabolismo, Hospitais da Universidade de Coimbra, Coimbra.
  • Margarida Bastos
  • Miguel Melo
  • Manuela Carvalheiro

DOI:

https://doi.org/10.20344/amp.844

Abstract

To assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR).We analysed the GFR measure by Tc99m-DTPA method and the estimated by the Cockroft Gault formula, in 21 subjects with type 1 or type 2 diabetes.There was a strong positive correlation between the two methods but the Cockroft Gault formula underestimated the GFR.The formula gives a accurate estimates of GFR, when GFR is <100 ml/min/1,73 m2. Beside the underestimation, the formula could be used in the management of diabetic nephropathy because the repeated isotope assessments of renal function are impracticable.

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How to Cite

1.
Guimarães J, Bastos M, Melo M, Carvalheiro M. Diabetic nephropathy: glomerular filtration rate and estimated creatinine clearance. Acta Med Port [Internet]. 2007 Apr. 30 [cited 2024 Nov. 8];20(2):145-50. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/844

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Section

Arquivo Histórico