@article{Correia_Augusto_Meireles_Pinto_Sousa_2016, place={Lisbon, Portugal}, title={Pediatric Multiple Sclerosis in Portugal: A Multicentre Study}, volume={29}, url={https://actamedicaportuguesa.com/revista/index.php/amp/article/view/6346}, DOI={10.20344/amp.6346}, abstractNote={<strong>Introduction:</strong> Multiple sclerosis is most often diagnosed among young adults but less frequently it may present during childhood or adolescence. In Portugal, there has been only one previous single-center, pediatric multiple sclerosis study. The main objective was the evaluation of the demographic, clinical, laboratorial and neuroradiological characteristics of patients with pediatric-onset multiple sclerosis in Portugal. The secondary objectives were to compare the characteristics of childhood-onset multiple sclerosis and adolescent-onset multiple sclerosis and to characterize the treatments prescribed.<br /><strong>Material and Methods:</strong> We performed a retrospective observational, multicentric study. We reviewed data of all patients with multiple sclerosis younger than 18 years at the onset of their first multiple sclerosis symptoms.<br /><strong>Results:</strong> There were 46 patients (72% female) included with a mean age at diagnosis of 16.1 years. Six cases had childhood-onset and 40 cases had adolescence-onset. The median value of Expanded Disability Status Scale was two. Relapsing-remitting multiple sclerosis was most prevalent (98% of cases). In the cerebrospinal fluid study, 74% of patients had positive oligoclonal bands. Brain magnetic resonance imaging studies showed a predominant supratentorial involvement (98% of cases), whereas the cervical segment was the most frequently affected in the spinal cord. All the patients enrolled in the study underwent immunomodulatory therapy, 75% of<br />patients with beta-interferon. Concerning differences between the childhood and the adolescent groups, we found a greater proportion of male patients and of individuals with cerebrospinal fluid pleocytosis among the childhood-onset group.<br /><strong>Discussion:</strong> This study provides new data on pediatric multiple sclerosis characteristics in Portugal and our results are similar to previously reported data in other parts of the world<br /><strong>Conclusion:</strong> This is the first multicentric study characterizing pediatric multiple sclerosis in Portugal. The mechanisms underlying the particularities of pediatric multiple sclerosis remain largely unknown and further studies are required.}, number={7-8}, journal={Acta Médica Portuguesa}, author={Correia, Ana Sofia and Augusto, Luís and Meireles, Joana and Pinto, Joana and Sousa, Ana Paula}, year={2016}, month={Aug.}, pages={425–431} }