TY - JOUR AU - Abreu, Pedro AU - Azevedo, Elsa AU - Lobo, Luís AU - Moura, Conceição Souto AU - Pontes, Celso PY - 2005/06/30 Y2 - 2024/03/28 TI - Whipple disease and central nervous system. JF - Acta Médica Portuguesa JA - Acta Med Port VL - 18 IS - 3 SE - DO - 10.20344/amp.1023 UR - https://actamedicaportuguesa.com/revista/index.php/amp/article/view/1023 SP - 199-208 AB - Whipple disease (WD) is a rare systemic infection caused by the bacteria Tropheryma whipplei. Slowly progressive dementia, supranuclear ophthalmoplegia, headache, myoclonus, hypothalamic dysfunction, oculomasticatory-skeletal myorythmia are characteristic manifestations when WD involves the central nervous system (CNS). Treatment of cerebral WD should be performed with antibiotics that reach the CNS for at the least one-year. We alert for the early diagnosis of WD in patients with exclusively neurological clinical pictures, sometimes with atypical or non-definitive diagnosis, because it is a potential treatable disease. ER -