TY - JOUR AU - Cosme, Joana AU - Spínola, Amélia AU - Ferreira, Manuel Branco AU - Barbosa, Manuel Pereira PY - 2019/11/04 Y2 - 2024/03/29 TI - Hospitalizations due to Angioedema without Urticaria in a Portuguese Center: Five Year Retrospective Study JF - Acta Médica Portuguesa JA - Acta Med Port VL - 32 IS - 11 SE - Original DO - 10.20344/amp.11893 UR - https://actamedicaportuguesa.com/revista/index.php/amp/article/view/11893 SP - 714-720 AB - <p><strong>Introduction:</strong> Hospitalizations due to angioedema are important especially in debilitating or life-threatening situations. The aim of this study was to evaluate the frequency and etiology of angioedema without urticaria in hospital admissions.<br /><strong>Material and Methods:</strong> The admissions between 2009 and 2013 in Centro Hospitalar Lisboa Norte with a diagnosis grouped under the ICD9 codes of angioedema were retrospectively analysed. The episodes of angioedema with urticaria were excluded. The admissions were categorized into 2 groups: A — hospitalizations motivated by the angioedema; B — hospitalizations in which the angioedema was an incidental finding.<br /><strong>Results:</strong> There were 169 hospitalizations (52% females, 96% adults, mean age 52 ± 20.8 years), distributed by 23 hospital departments, 51% in the Immunoallergology department. The mean annual angioedema admission rate was 72/100 000. In 68% of the cases, angioedema was the cause for the admission; in 32% an incidental finding. In 38% there was upper airway involvement. The etiologies were: hereditary angioedema in 24%, angiotensin converting enzyme inhibitor induced angioedema in 31%, idiopathic angioedema in 21%, thrombolysis induced angioedema in 13%, nonsteroidal anti-inflammatory drug-induced angioedema in 5%.<br /><strong>Discussion:</strong> The main etiology was angiotensin converting enzyme inhibitor angioedema, followed by hereditary angioedema and thrombolysis induced angioedema, and these findings concur with the international literature.<br /><strong>Conclusion:</strong> The mean annual angioedema admission rate was 72/100 000 and there was airway involvement in 38% of hospitalizations.</p> ER -