TY - JOUR AU - Boal Carvalho, Pedro AU - Magalhães, Joana AU - Dias de Castro, Francisca AU - Rosa, Bruno AU - Cotter, José PY - 2017/03/31 Y2 - 2024/03/28 TI - Randomized Controlled Trial for Helicobacter pylori Eradication in a Naive Portuguese Population: Is Sequential Treatment Superior to Triple Therapy in Real World Clinical Setting? JF - Acta Médica Portuguesa JA - Acta Med Port VL - 30 IS - 3 SE - Original DO - 10.20344/amp.8072 UR - https://actamedicaportuguesa.com/revista/index.php/amp/article/view/8072 SP - 185-189 AB - <p><strong>Introduction:</strong> Helicobacter pylori eradication has become increasingly difficult as resistances to several antibiotics develop. We aimed to compare Helicobacter pylori eradication rates between triple therapy and sequential therapy in a naive Portuguese population.<br /><strong>Material and Methods:</strong> Prospective randomized trial including consecutive patients referred for first-line Helicobacter pylori eradication treatment. Exclusion criteria: previous gastric surgery/neoplasia, pregnancy/lactancy, allergy to any of the drugs. The compared eradication regimens were triple therapy (pantoprazol, amoxicillin and clarithromycin 12/12 hours, 14 days) and sequential therapy (pantoprazol 12/12 hours for 10 days, amoxicillin 12/12 hours for days 1 - 5 and clarithromycin plus metronidazol 12/12 hours during days 6 - 10). Eradication success was confirmed with urea breath test. Statistical analysis was performed with SPSS v21.0 and a p-value &lt; 0.05 was considered statistically significant.<br /><strong>Results:</strong> Included 60 patients, 39 (65%) female with mean age 52 years (SD ± 14.3). Treatment groups were homogeneous for gender, age, indication for treatment and smoking status. No statistical differences were encountered between sequential and triple therapy eradication rates (86.2% vs 77.4%, p = 0.379), global eradication rate was 82%. Tobacco consumption was associated with a significantly lower eradication success (54.5 vs 87.8%, p = 0.022).<br /><strong>Discussion:</strong> In this randomized controlled trial in a naive Portuguese population, we found a satisfactory global Helicobacter pylori eradication rate of 82%, with no statistical differences observed in the efficacy of the treatment between triple and sequential regimens.<br /><strong>Conclusion:</strong> These results support the use of either therapy for the first-line eradication of Helicobacter pylori.</p> ER -