Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469

Inês Leal; David Cordeiro Sousa; João Costa; António Vaz-Carneiro

doi:10.20344/amp.10660

Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469

Authors

Inês Leal Serviço de Oftalmologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Centro de Estudos das Ciências da Visão. Faculdade de Medicina. Universidade de Lisboa. Lisboa.
David Cordeiro Sousa Serviço de Oftalmologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Centro de Estudos das Ciências da Visão. Faculdade de Medicina. Universidade de Lisboa. Lisboa.
João Costa Centro de Estudos de Medicina Baseada na Evidência. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Centro Colaborador Português da Rede Cochrane Iberoamericana. Faculdade de Medicina. Universidade de Lisboa. Lisboa.
António Vaz-Carneiro Centro de Estudos de Medicina Baseada na Evidência. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Centro Colaborador Português da Rede Cochrane Iberoamericana. Faculdade de Medicina. Universidade de Lisboa. Lisboa.

DOI:

https://doi.org/10.20344/amp.10660

Keywords:

Adrenal Cortex Hormones/administration & dosage, Drug Implants, Randomized Controlled Trials as Topic, Uveitis/drug therapy

Abstract

Non-infectious uveitis is a heterogeneous collection of inflammatory eye diseases and is one of the most important causes of blindness among active adults in developed countries. Inflammation control is crucial in the prevention of ocular structural and functional damage. Regarding acute inflammatory control, corticosteroids are the mainstay of treatment. Several types of intra-ocular corticosteroids have been used with the aim of enhanced efficacy compared to their topical or peri-ocular administration, while minimizing its adverse effects associated with the systemic administration. The purpose of this Cochrane review was to synthetize the available evidence regarding the efficacy and safety of corticosteroid implants in comparison with standard treatment. Due to the heterogeneity in the design of the studies and outcome measures assessed, authors could not conclude that implants are superior to traditional systemic therapy in Non-infectious uveitis. The safety analysis suggested increased risks of post-implant surgery for cataract and high intraocular pressure compared with standard-of-care therapy.

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Author Biographies

Inês Leal, Serviço de Oftalmologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Centro de Estudos das Ciências da Visão. Faculdade de Medicina. Universidade de Lisboa. Lisboa.

Assistente Hospitalar, Serviço de Oftalmologia, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte

Departamento de Etica e Deontologia Medicas, Assistente Convidada, Faculdade de Medicina de Lisboa

David Cordeiro Sousa, Serviço de Oftalmologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Centro de Estudos das Ciências da Visão. Faculdade de Medicina. Universidade de Lisboa. Lisboa.

Interno de Oftalmologia, Serviço de Oftalmologia, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte

Assistente Convidado, Faculdade de Medicina de Lisboa

António Vaz-Carneiro, Centro de Estudos de Medicina Baseada na Evidência. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Centro Colaborador Português da Rede Cochrane Iberoamericana. Faculdade de Medicina. Universidade de Lisboa. Lisboa.

Diretor, Instituto de Medicina Preventiva e Saúde Pública

Diretor, Instituto de Saúde Ambiental

Diretor, Centro de Estudos de Medicina Baseada na Evidência

Diretor-Executivo, Instituto de Formação Avançada

Professor Bibliotecário, BC-CDI

Diretor, Cochrane Portugal

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Published

2018-05-30

How to Cite

Leal I, Sousa DC, Costa J, Vaz-Carneiro A. Analysis of the Cochrane Review: Cortisteroid Implants for Chronic Non-Infectious Uveitis. Cochrane Database Syst Rev. 2016;2:CD010469. Acta Med Port [Internet]. 2018 May 30 [cited 2024 Nov. 21];31(5):243-6. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/10660

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Issue

Vol. 31 No. 5 (2018): May

Section

Cochrane Corner

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