Venetoclax: A New Hope for Elderly Patients with Acute Myeloid Leukemia


  • Bárbara Marques Serviço de Hematologia Clínica. Centro Hospitalar e Universitário de Coimbra. Coimbra.
  • Carolina Afonso Serviço de Hematologia Clínica. Centro Hospitalar e Universitário de Coimbra. Coimbra.
  • Emília Cortesão Serviço de Hematologia Clínica. Centro Hospitalar e Universitário de Coimbra. Coimbra.



Aged, Bridged Bicyclo Compounds, Heterocyclic, Leukemia, Myeloid, Acute/drug therapy


Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by clonal proliferation, with increased incidence with advancing age. AML with myelodysplasia-related changes (AML-MRC) represents an AML subtype with a poor prognosis and challenging treatment, particularly in elderly patients. We report the case of a 77-year-old patient diagnosed with high-risk AML-MRC, ineligible for intensive chemotherapy, with frequent need of transfusion of red cell concentrates. The authors present, to the best of their knowledge, the first patient in Portugal with AML-MRC treated with an hypomethylating agent, azacytidine, and a BCL2 inhibitor (venetoclax), and that association was essential in the treatment and overall survival, which was much higher than expected.


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How to Cite

Marques B, Afonso C, Cortesão E. Venetoclax: A New Hope for Elderly Patients with Acute Myeloid Leukemia. Acta Med Port [Internet]. 2022 Mar. 29 [cited 2024 Apr. 12];36(1):59-62. Available from:



Case Report