Fractional Exhaled Nitric Oxide in Monitoring and Therapeutic Management of Asthma

Authors

  • Bruno Melo Escola de Ciências da Saúde. Universidade do Minho. Braga. Portugal.
  • Patrício Costa Saúde Comunitária. Escola de Ciências da Saúde. Universidade do Minho. Braga. Portugal.
  • Ariana Afonso Serviço de Pediatria. Hospital de Braga. Braga. Portugal.
  • Vânia Machado Serviço de Pediatria. Hospital de Braga. Braga. Portugal.
  • Carla Moreira Serviço de Pediatria. Hospital de Braga. Braga. Portugal.
  • Augusta Gonçaves Serviço de Pediatria. Hospital de Braga. Braga. Portugal.
  • Jean-Pierre Gonçalves Saúde Comunitária. Escola de Ciências da Saúde. Universidade do Minho. Braga. Portugal. Serviço de Pediatria. Hospital de Braga. Braga. Portugal.

DOI:

https://doi.org/10.20344/amp.2371

Abstract

Introduction: Asthma is a chronic respiratory disease characterized by hyper-responsiveness and bronchial inflammation. The bronchial inflammation in these patients can be monitored by measuring the fractional exhaled nitric oxide. This study aims to determine fractional exhaled nitric oxide association with peak expiratory flow and with asthma control inferred by the Global Initiative for Asthma.
Material and Methods: Observational, analytical and cross-sectional study of children with asthma, 6-12 years-old, followed in the Outpatient Respiratory Pathology of Braga Hospital. Sociodemographic and clinical information were collected through a questionnaire. fractional exhaled nitric oxide and peak expiratory flow were determined by portable analyzer Niox Mino® and flow meter, respectively.
Results: The sample is constituted by 101 asthmatic children, 63 (62.4%) of males and 38 (37.6%) females. The mean age of participants in the sample is 9.18 (1.99) years. The logistic regression performed with the cutoff value obtained by ROC curve, revealed that fractional exhaled nitric oxide (bFENO classes = 0.85; χ2 Wald (1) = 8.71; OR = 2.33; p = 0.003) has a statistical significant effect on the probability of changing level of asthma control. The odds ratio of going from “controlled” to “partly controlled/uncontrolled” is 2.33 per each level of fractional exhaled nitric oxide.
Discussion and Conclusion: The probability of an asthmatic children change their level of asthma control, from ‘controlled’ to ‘partly controlled/uncontrolled’, taking into account a change in their fractional exhaled nitric oxide level, increases 133%.

Downloads

Download data is not yet available.

Author Biographies

Bruno Melo, Escola de Ciências da Saúde. Universidade do Minho. Braga. Portugal.

Patrício Costa, Saúde Comunitária. Escola de Ciências da Saúde. Universidade do Minho. Braga. Portugal.

Ariana Afonso, Serviço de Pediatria. Hospital de Braga. Braga. Portugal.

Vânia Machado, Serviço de Pediatria. Hospital de Braga. Braga. Portugal.

Carla Moreira, Serviço de Pediatria. Hospital de Braga. Braga. Portugal.

Augusta Gonçaves, Serviço de Pediatria. Hospital de Braga. Braga. Portugal.

Jean-Pierre Gonçalves, Saúde Comunitária. Escola de Ciências da Saúde. Universidade do Minho. Braga. Portugal. Serviço de Pediatria. Hospital de Braga. Braga. Portugal.

Published

2014-01-08

How to Cite

1.
Melo B, Costa P, Afonso A, Machado V, Moreira C, Gonçaves A, Gonçalves J-P. Fractional Exhaled Nitric Oxide in Monitoring and Therapeutic Management of Asthma. Acta Med Port [Internet]. 2014 Jan. 8 [cited 2024 Mar. 28];27(1):59-66. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/2371