Prognostic Factors after Liver Resection for Colorectal Liver Metastasis

Authors

  • Margarida Matias Department of Medical Oncology. Centro Hospitalar Lisboa Norte. Lisbon. Portugal.
  • Mafalda Casa-Nova Department of Medical Oncology. Centro Hospitalar Lisboa Norte. Lisbon. Portugal.
  • Mariana Faria Department of Medical Oncology. Centro Hospitalar Lisboa Norte. Lisbon. Portugal.
  • Ricardo Pires Clinical and Translational Research Oncology Unit. Instituto de Medicina Molecular. Lisbon. Portugal.
  • Joana Tato-Costa Clinical and Translational Research Oncology Unit. Instituto de Medicina Molecular. Lisbon. Portugal.
  • Leonor Ribeiro Department of Medical Oncology. Centro Hospitalar Lisboa Norte. Lisbon. Portugal.
  • Luis Costa Department of Medical Oncology. Centro Hospitalar Lisboa Norte. Lisbon. Portugal.

DOI:

https://doi.org/10.20344/amp.4816

Keywords:

Colorectal Neoplasms, Hepatectomy, Liver Neoplasms/secondary, Liver Neoplasms/surgery, Prognosis.

Abstract

Introduction: Surgery is the only potentially curative treatment for patients with colorectal liver metastases, resulting in 5-year survival rates of 36–58%. Although many studies have been performed to determine prognostic factors for tumor recurrence and survival after resection of colorectal liver metastases, there are few prognostic scoring systems stratifying patients undergoing surgery for colorectal liver metastases into risk group models.
Objectives: To identify, evaluate and compare the existing prognostic scores for survival after surgery for resection of colorectal liver metastases.
Material and Methods: Electronic search in PubMed, Cochrane and Embase from 1990 to 2013 using the terms ‘hepatic resection’, ‘colorectal cancer’, ‘liver metastasis’, ‘hepatectomy’, ‘prognostic’, and ‘score‘. Only studies proposing a prognostic model or risk stratification based on clinical and/or pathological variables were included.
Results: From 1996 to June 2013, 19 scoring systems were identified, including one nomogram. Thirty prognostic factors were identified although none of the factors was common to all prognostic models. The 4 factors most often included were: number of liver metastases, regional lymph node metastization of primary tumor, preoperative CEA level and maximum size of metastases. The median study sample size was 305 patients (81-1 568 patients) and median follow-up was 33 months (16-54 months). All studies were retrospective and used the Cox proportional hazards model for multi-variable analysis.
Conclusion: Several factors have been constantly reported as having prognostic value after liver resection of colorectal liver
metastases, although there is no consensus on the ideal scoring system.

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Author Biographies

Margarida Matias, Department of Medical Oncology. Centro Hospitalar Lisboa Norte. Lisbon. Portugal.

University degree in Medicine

Specialist in Medical Oncology - Hospital de Santa Maria, CHLN

Now working at Medical Oncology Department at Institut Gustave Roussy, Villejuif, France

 

Mafalda Casa-Nova, Department of Medical Oncology. Centro Hospitalar Lisboa Norte. Lisbon. Portugal.

University degree in Medicine

Speciality on Medical Oncology

Mariana Faria, Department of Medical Oncology. Centro Hospitalar Lisboa Norte. Lisbon. Portugal.

University degree in Medicine

Internship of Medical Oncology

Ricardo Pires, Clinical and Translational Research Oncology Unit. Instituto de Medicina Molecular. Lisbon. Portugal.

University degree in Biology

Investigator on the Clinical and Translational Research Oncology Unit, Lisbon, Portugal

Joana Tato-Costa, Clinical and Translational Research Oncology Unit. Instituto de Medicina Molecular. Lisbon. Portugal.

University degree in Biology

Investigator on the Clinical and Translational Research Oncology Unit, Lisbon, Portugal

Leonor Ribeiro, Department of Medical Oncology. Centro Hospitalar Lisboa Norte. Lisbon. Portugal.

University degree in Medicine

Speciality on Internal Medicine and Medical Oncology

Luis Costa, Department of Medical Oncology. Centro Hospitalar Lisboa Norte. Lisbon. Portugal.

University degree in Medicine.

Speciality on Internal Medicine and Medical Oncology.

Director of the Oncology Division at Hospital de Santa MariaProfessor of Medicine & Biology of Cancer – Faculdade de Medicina de Lisboa

Principal Investigator of Instituto de Medicina Molecular (IMM) – Research Leader of The Clinical Translational Oncology Research Unit at IMM.

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Published

2015-02-27

How to Cite

1.
Matias M, Casa-Nova M, Faria M, Pires R, Tato-Costa J, Ribeiro L, Costa L. Prognostic Factors after Liver Resection for Colorectal Liver Metastasis. Acta Med Port [Internet]. 2015 Feb. 27 [cited 2024 Feb. 29];28(3):357-69. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/4816

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Section

Review Articles