Hypothyroidism Associated to TSH Hormone-Receptor Autoantibodies with Blocking Activity Assessed In Vitro

Authors

  • Pedro Marques Serviço de Endocrinologia. Instituto Português de Oncologia Dr. Francisco Gentil. Lisboa. Portugal.
  • Karim Chikh Departamento de Bioquímica. CARMEN Laboratory. University Claude Bernard Lyon. Lyon Sud Hospital. Hospices Civils de Lyon. Lyon. França.
  • Anne Charrié Departamento de Bioquímica. CARMEN Laboratory. University Claude Bernard Lyon. Lyon Sud Hospital. Hospices Civils de Lyon. Lyon. França.
  • Rosa Pina Serviço de Endocrinologia Pediátrica. Hospital Dona Estefânia. Centro Hospitalar de Lisboa Central. Lisboa. Portugal.
  • Maria João Bugalho Serviço de Endocrinologia. Instituto Português de Oncologia Dr. Francisco Gentil. Lisboa. Portugal.
  • Lurdes Lopes Serviço de Endocrinologia Pediátrica. Hospital Dona Estefânia. Centro Hospitalar de Lisboa Central. Lisboa. Portugal.

DOI:

https://doi.org/10.20344/amp.6521

Keywords:

Graves Disease, Hypothyroidism, Receptors, Thyrotropin, Thyroiditis, Autoimmune.

Abstract

Thyroid-stimulating hormone-receptor autoantibodies normally causes hyperthyroidism. However, they might have blocking activity causing hypothyroidism. A 11-year-old girl followed due to type 1 diabetes mellitus, celiac disease and euthyroid lymphocytic thyroiditis at diagnosis. Two years after the initial evaluation, thyroid-stimulating hormone was suppressed with normal free T4; nine months later, a biochemical evolution to hypothyroidism with thyroid-stimulating hormone-receptor autoantibodies elevation was seen; the patient remained always asymptomatic. Chinese hamster ovary cells were transfected with the recombinant human thyroid-stimulating hormone -receptor, and then exposed to the patient´s serum; it was estimated a ‘moderate’ blocking activity of these thyroid-stimulating hormone-receptor autoantibodies, and concomitantly excluded stimulating action. In this case, the acknowledgment of the blocking activity of the serum thyroid-stimulating hormone-receptor autoantibodies, supported the hypothesis of a multifactorial aetiology of the hypothyroidism, which in the absence of the in vitro tests, we would consider only as a consequence of the destructive process associated to lymphocytic thyroiditis.

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Author Biographies

Pedro Marques, Serviço de Endocrinologia. Instituto Português de Oncologia Dr. Francisco Gentil. Lisboa. Portugal.

Serviço de Endocrinologia

Karim Chikh, Departamento de Bioquímica. CARMEN Laboratory. University Claude Bernard Lyon. Lyon Sud Hospital. Hospices Civils de Lyon. Lyon. França.

Departamento de Bioquímica

Anne Charrié, Departamento de Bioquímica. CARMEN Laboratory. University Claude Bernard Lyon. Lyon Sud Hospital. Hospices Civils de Lyon. Lyon. França.

Departamento de Bioquímica

Rosa Pina, Serviço de Endocrinologia Pediátrica. Hospital Dona Estefânia. Centro Hospitalar de Lisboa Central. Lisboa. Portugal.

Serviço de Endocrinologia Pediátrica

Maria João Bugalho, Serviço de Endocrinologia. Instituto Português de Oncologia Dr. Francisco Gentil. Lisboa. Portugal.

Serviço de Endocrinologia

Lurdes Lopes, Serviço de Endocrinologia Pediátrica. Hospital Dona Estefânia. Centro Hospitalar de Lisboa Central. Lisboa. Portugal.

Serviço de Endocrinologia Pediátrica

Published

2015-09-11

How to Cite

1.
Marques P, Chikh K, Charrié A, Pina R, Bugalho MJ, Lopes L. Hypothyroidism Associated to TSH Hormone-Receptor Autoantibodies with Blocking Activity Assessed In Vitro. Acta Med Port [Internet]. 2015 Sep. 11 [cited 2024 Mar. 29];28(5):663-6. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/6521