Advanced Stage Hepatocellular Carcinoma with Multiple Metastasis and Vascular Thrombosis: A Case of Complete Response to Sorafenib

Authors

  • Adélia Simão Serviço de Medicina Interna A. Centro Hospitalar e Universitário de Coimbra. Coimbra. Departamento de Medicina. Faculdade de Medicina. Universidade de Coimbra. Coimbra.
  • Raquel Silva Serviço de Medicina Interna A. Centro Hospitalar e Universitário de Coimbra. Coimbra. Departamento de Medicina. Faculdade de Medicina. Universidade de Coimbra. Coimbra.
  • Lurdes Correia Serviço de Medicina Interna A. Centro Hospitalar e Universitário de Coimbra. Coimbra. Departamento de Medicina. Faculdade de Medicina. Universidade de Coimbra. Coimbra.
  • Filipe Caseiro Alves Departamento de Radiologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Departamento de Radiologia. Faculdade de Medicina. Universidade de Coimbra. Coimbra.
  • Armando Carvalho Serviço de Medicina Interna A. Centro Hospitalar e Universitário de Coimbra. Coimbra. Departamento de Medicina. Faculdade de Medicina. Universidade de Coimbra. Coimbra.
  • J. M. Nascimento Costa Serviço de Medicina Interna A. Centro Hospitalar e Universitário de Coimbra. Coimbra. Departamento de Medicina. Faculdade de Medicina. Universidade de Coimbra. Coimbra.

DOI:

https://doi.org/10.20344/amp.6799

Keywords:

Carcinoma, Hepatocellular/drug therapy, Neoplasm Metastasis, Remission Induction, Sorafenib.

Abstract

Sorafenib is a multi-targeted tyrosine kinase inhibitor, with antiangiogenic and antiproliferative properties, approved for the treatment of advanced hepatocellular carcinoma. It induces a significant increase in the median overall survival, despite a complete response to treatment being rare. We report a clinical case of a 60-year-old male with hepatic cirrhosis, Child-Pugh class A and performance status 0, and advanced hepatocellular carcinoma. The primary tumor measured 17 x 8 cm and had diffuse intrahepatic metastization, extensive lung and left adrenal invasion, as well as thrombosis of inferior vena cava, with projection to the right atrium. This patient showed a rapid and complete response to sorafenib, evaluated by mRECIST (modified Response Evaluation Criteria in Solid Tumors), that remains after three years of treatment.

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Published

2016-02-29

How to Cite

1.
Simão A, Silva R, Correia L, Alves FC, Carvalho A, Costa JMN. Advanced Stage Hepatocellular Carcinoma with Multiple Metastasis and Vascular Thrombosis: A Case of Complete Response to Sorafenib. Acta Med Port [Internet]. 2016 Feb. 29 [cited 2023 Jan. 31];29(2):139-42. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/6799

Issue

Section

Case Report