Safety and Effectiveness of Cataract Surgery with Simultaneous Intravitreal Anti-VEGF in Patients with Previously Treated Exudative Age-Related Macular Degeneration

Manuel Sousa Falcão; Paulo Freitas-Costa; João Nuno Beato; João Pinheiro-Costa; Amândio Rocha-Sousa; Ângela Carneiro; Elisete Maria Brandão; Fernando Falcão-Reis

doi:10.20344/amp.7850

Safety and Effectiveness of Cataract Surgery with Simultaneous Intravitreal Anti-VEGF in Patients with Previously Treated Exudative Age-Related Macular Degeneration

Authors

Manuel Sousa Falcão Ophthalmology Department. Centro Hospitalar São João. Porto. Portugal. Department of Sense Organs. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
Paulo Freitas-Costa Ophthalmology Department. Centro Hospitalar São João. Porto. Portugal. Department of Anatomy. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
João Nuno Beato Ophthalmology Department. Centro Hospitalar São João. Porto. Portugal. Department of Sense Organs. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
João Pinheiro-Costa Ophthalmology Department. Centro Hospitalar São João. Porto. Portugal. Department of Anatomy. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
Amândio Rocha-Sousa Ophthalmology Department. Centro Hospitalar São João. Porto. Portugal. Department of Sense Organs. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
Ângela Carneiro Ophthalmology Department. Centro Hospitalar São João. Porto. Portugal. Department of Sense Organs. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
Elisete Maria Brandão Department of Sense Organs. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
Fernando Falcão-Reis Ophthalmology Department. Centro Hospitalar São João. Porto. Portugal. Department of Sense Organs. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

DOI:

https://doi.org/10.20344/amp.7850

Keywords:

Cataract Extraction, Macular Degeneration, Neovascularization, Phacoemulsification, Treatment Outcome, Vascular Endothelial Growth Factors

Abstract

Introduction: To evaluate the safety and impact on visual acuity, retinal and choroidal morphology of simultaneous cataract surgery and intravitreal anti-vascular endothelial growth factor on patients with visually significant cataracts and previously treated exudative age-related macular degeneration.
Material and Methods: Prospective study, which included 21 eyes of 20 patients with exudative age-related macular degeneration submitted to simultaneous phacoemulsification and intravitreal ranibizumab or bevacizumab. The patients were followed for 12 months after surgery using a pro re nata strategy. Visual acuity, foveal and choroidal thickness changes were evaluated 1, 6 and 12 months post-operatively.
Results: There was a statistically significant increase in mean visual acuity at one (13.4 letters, p < 0.05), six (11.5 letters, p < 0.05) and twelve months (11.3 letters, p < 0.05) without significant changes in retinal or choroidal morphology. At 12 months, 86% of eyes were able to maintain visual acuity improvement. There were no significant differences between the two anti-vascular endothelial growth factor drugs and no complications developed during follow-up.
Discussion: Simultaneous phacoemulsification and intravitreal anti- vascular endothelial growth factor is safe and allows improvement in visual acuity in patients with visually significant cataracts and exudative age-related macular degeneration. Visual acuity gains were maintained with a pro re nata strategy showing that in this subset of patients, phacoemulsification may be beneficial.
Conclusion: Cataract surgery and simultaneous anti-vascular endothelial growth factor therapy improves visual acuity in patients with exudative age-related macular degeneration.

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Published

2017-02-27

How to Cite

Falcão MS, Freitas-Costa P, Beato JN, Pinheiro-Costa J, Rocha-Sousa A, Carneiro Ângela, Brandão EM, Falcão-Reis F. Safety and Effectiveness of Cataract Surgery with Simultaneous Intravitreal Anti-VEGF in Patients with Previously Treated Exudative Age-Related Macular Degeneration. Acta Med Port [Internet]. 2017 Feb. 27 [cited 2024 Nov. 4];30(2):127-33. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/7850

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Issue

Vol. 30 No. 2 (2017): February

Section

Original

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