Atrial Fibrillation in Cerebrovascular Disease: National Neurological Perspective

Authors

  • Joao Sargento-Freitas Unidade de Acidente Vascular Cerebral, Serviço de Neurologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal
  • Fernando Silva Unidade de Acidente Vascular Cerebral, Serviço de Neurologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal
  • Sebastian Koehler Faculdade de Medicina da Universidade de Coimbra. Coimbra. Portugal.
  • Luís Isidoro Unidade de Acidente Vascular Cerebral, Serviço de Neurologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal
  • Nuno Mendonça Unidade de Acidente Vascular Cerebral, Serviço de Neurologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal
  • Cristina Machado Unidade de Acidente Vascular Cerebral, Serviço de Neurologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal
  • Gustavo Cordeiro Unidade de Acidente Vascular Cerebral, Serviço de Neurologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal
  • Luís Cunha Unidade de Acidente Vascular Cerebral, Serviço de Neurologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal

DOI:

https://doi.org/10.20344/amp.85

Abstract

Background: Cardioembolism due to atrial fibrillation assumes a dominant etiologic role in cerebrovascular diseases due to its growing incidence, high embolic risk and particular aspects of clinical events caused. Our objectives are to analyze the frequency of atrial fibrillation in patients with ischemic stroke, study the vital and functional impact of stroke due to different etiologies and evaluate antithrombotic options before and after stroke. Methods: We conducted a retrospective study including patients admitted in a central hospital due to ischemic stroke in 2010 (at least one year of follow-up). Etiology of stroke was defined using the Trial of ORG 10172 in Acute Stroke (TOAST) classification, and functional outcome by modified Rankin scale. We performed a descriptive analysis of different stroke etiologies and antithrombotic medication in patients with atrial fibrillation. We then conducted a cohort study to evaluate the clinical impact of antithrombotic options in secondary prevention after cardioembolic stroke. Results: In our population (n = 631) we found superior frequency of cardioembolism (34.5%) to that reported in the literature. Mortality, morbidity and antithrombotic options are similar to other previous series, confirming the severity of cardioembolic strokes and the underuse of vitamin K antagonists. Oral anticoagulation was effective in secondary prevention independently from post-stroke functional condition. Conclusions: Despite unequivocal recommendations, oral anticoagulation is still underused in stroke prevention. This study confirms the clinical efficacy of vitamin K antagonists in secondary prevention independently from residual functional impairment.

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Author Biography

Joao Sargento-Freitas, Unidade de Acidente Vascular Cerebral, Serviço de Neurologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal

Membro da equipa clínica da Unidade de AVC e Laboratório de Neurossonologia dos CHUC-HUC.

Published

2013-06-05

How to Cite

1.
Sargento-Freitas J, Silva F, Koehler S, Isidoro L, Mendonça N, Machado C, Cordeiro G, Cunha L. Atrial Fibrillation in Cerebrovascular Disease: National Neurological Perspective. Acta Med Port [Internet]. 2013 Jun. 5 [cited 2024 Mar. 28];26(2):86-92. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/85