Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.

Authors

  • Catarina Soares Queirós Serviço de Dermatologia. Hospital de Santa Maria. Lisboa. Portugal.
  • Gonçalo Silva Duarte Laboratório de Farmacologia Clínica e Terapêutica. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal. Clinical Pharmacology Unit. Instituto de Medicina Molecular. Lisboa. Portugal. Centro de Estudos de Medicina Baseada na Evidência. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.
  • João Costa Laboratório de Farmacologia Clínica e Terapêutica. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal. Clinical Pharmacology Unit. Instituto de Medicina Molecular. Lisboa. Portugal. Centro de Estudos de Medicina Baseada na Evidência. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.
  • António Vaz-Carneiro Centro de Estudos de Medicina Baseada na Evidência. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal. Centro Colaborador Português da Rede Cochrane Iberoamericana. Lisboa. Portugal.

DOI:

https://doi.org/10.20344/amp.8910

Keywords:

Administration, Topical, Dermatologic Agents/therapeutic use, Psoriasis/therapy, Scalp Dermatoses/therapy, Steroids, Systematic Review, Vitamin D

Abstract

Regardless the psoriasis subtype, up to 79% of people with this skin condition present scalp involvement, which is often the first site to show symptoms of the disease. In addition to being itchy, the red and scaly lesions are usually easy to see, and may be embarrassing. Topical therapy is usually the first line of treatment; however the wide array of available interventions can make the choice difficult, and may even lead to an inadequate treatment. The objective of this review was to evaluate the efficacy and safety of topical treatments for scalp psoriasis. A systematic review was performed according to the methodology recommended by Cochrane in order to evaluate the clinical severity of psoriasis, quality of life, and adverse events that led to treatment discontinuation. To evaluate this, 59 studies were included, with a total of 11 561 participants, and 15 comparisons were made between the various drugs and application vehicles tested. The principal conclusion is that corticosteroids of high or very high potency are more effective than vitamin D. The combination of a corticosteroid with vitamin D has only a marginal benefit over corticosteroid monotherapy, but is superior to vitamin D alone. Given the similar safety profile and only marginal benefit of the combination of corticosteroid with vitamin D over the corticosteroid alone, topical corticosteroid monotherapy appears to be fully acceptable for short-term therapy of scalp psoriasis.

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Published

2017-03-31

How to Cite

1.
Queirós CS, Duarte GS, Costa J, Vaz-Carneiro A. Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687. Acta Med Port [Internet]. 2017 Mar. 31 [cited 2024 Nov. 14];30(3):163-8. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/8910

Issue

Section

Cochrane Corner