Systemic Lupus Erythematosus and Pregnancy

Abstract

Systemic lupus erythematosus is a chronic inflammatory disease, resulting from an auto-immune dysfunction. The etiology of this diseaseis unknown. It frequently occurs in women of childbearing age. Pregnancy in patients with systemic lupus erythematosus may beassociated with several complications (maternal, obstetrical and fetal). The prognosis for both mother and child is better when systemiclupus erythematosus has been quiescent for at least six months before pregnancy. Thus, preconceptional assessment and managementis crucial for helping women to achieve a period of disease remission before pregnancy as well as for allowing an adjustment oftherapy. Maternal health and fetal development should be closely monitored during pregnancy. These patients should be surveilled by amultidisciplinary team (obstetrician, rheumatologist or internist, nephrologist if necessary and a pediatrician), in a tertiary care hospital.Antiphospholipid syndrome, positivity for anti-SSA/Ro or anti-SSB/LA antibodies, hypertension or renal involvement are associatedwith an increase of adverse pregnancy outcomes. In this article the authors review the main aspects of Systemic lupus erythematosus(SLE) and pregnancy.