Long-Term High-Flow Nasal Cannula in Chronic Respiratory Failure in a Patient with Bronchiectasis
DOI:
https://doi.org/10.20344/amp.23254Keywords:
Bronchiectasis/therapy, Cannula, Oxygen Inhalation Therapy, Respiratory Insufficiency/therapyAbstract
High-flow nasal cannula (HFNC) is a gas delivery system that provides heated and humidified air at higher flow rates than conventional oxygen therapy. While studies on the role of HFNC as a long-term treatment for chronic respiratory failure are limited, most of them focus on patients with chronic obstructive pulmonary disease. We present the case of a woman with severe bronchiectasis and chronic hypercapnic respiratory failure under nocturnal non-invasive ventilation (NIV) and 24-hour conventional oxygen therapy, who experienced multiple and prolonged hospital admissions. Long-term daytime HFNC was initiated, maintaining nocturnal NIV, resulting in significant improvements in dyspnea, better secretion management, and a reduction in exacerbation rates. While more research is needed, HFNC should be considered for long-term management of chronic respiratory failure in patients with bronchiectasis.
Downloads
References
Dysart K, Miller TL, Wolfson MR, Shaffer TH. Research in high flow therapy: mechanisms of action. Respir Med. 2009;103:1400-5. DOI: https://doi.org/10.1016/j.rmed.2009.04.007
Goligher EC, Slutsky AS. Not just oxygen? Mechanisms of benefit from high-flow nasal cannula in hypoxemic respiratory failure. Am J Respir Crit Care Med. 2017;195:1128-31. DOI: https://doi.org/10.1164/rccm.201701-0006ED
Volpi V, Volpato E, Compalati E, Lebret M, Russo G, Sciurello S, et al. Efficacy of nasal high-flow oxygen therapy in chronic obstructive pulmonary disease patients in long-term oxygen and nocturnal non-invasive ventilation during exercise training. Healthcare. 2022;10:2001. DOI: https://doi.org/10.3390/healthcare10102001
Rea H, McAuley S, Jayaram L, Garrett J, Hockey H, Storey L, et al. The clinical utility of long-term humidification therapy in chronic airway disease. Respir Med. 2010;104:525-33. DOI: https://doi.org/10.1016/j.rmed.2009.12.016
Good WR, Garrett J, Hockey HU, Jayaram L, Wong C, Rea H. The role of high-flow nasal therapy in bronchiectasis: a post hoc analysis. ERJ Open Res. 2021;7:00711-2020. DOI: https://doi.org/10.1183/23120541.00711-2020
Crimi C, Nolasco S, Campisi R, Nigro M, Impellizzeri P, Cortegiani A, et al. Long-term domiciliary high-flow nasal therapy in patients with bronchiectasis: a preliminary retrospective observational case-control study. J Clin Med. 2022;11:7323. DOI: https://doi.org/10.3390/jcm11247323
Simioli F, Fiorentino G, Cauteruccio R, Coppola A, Imitazione P, Marotta A, et al. Long-term high flow nasal cannula therapy in primary and secondary bronchiectasis. Healthcare. 2023;11:1250. DOI: https://doi.org/10.3390/healthcare11091250
Elshof J, Duiverman ML. Clinical evidence of nasal high-flow therapy in chronic obstructive pulmonary disease patients. Respiration. 2020;99:140-53. DOI: https://doi.org/10.1159/000505583
Candia C, Lombardi C, Merola C, Ambrosino P, D’Anna SE, Vicario A, et al. The role of high-flow nasal cannula oxygen therapy in exercise testing and pulmonary rehabilitation: a review of the current literature. J Clin Med. 2023;13:232. DOI: https://doi.org/10.3390/jcm13010232
Weinreich UM, Juhl KS, Søby Christophersen M, Gundestrup S, Hanifa MA, Jensen K, et al. The Danish respiratory society guideline for long-term high flow nasal cannula treatment, with or without supplementary oxygen. Eur Clin Respir J. 2023;10:2178600. DOI: https://doi.org/10.1080/20018525.2023.2178600
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Acta Médica Portuguesa

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All the articles published in the AMP are open access and comply with the requirements of funding agencies or academic institutions. The AMP is governed by the terms of the Creative Commons ‘Attribution – Non-Commercial Use - (CC-BY-NC)’ license, regarding the use by third parties.
It is the author’s responsibility to obtain approval for the reproduction of figures, tables, etc. from other publications.
Upon acceptance of an article for publication, the authors will be asked to complete the ICMJE “Copyright Liability and Copyright Sharing Statement “(http://www.actamedicaportuguesa.com/info/AMP-NormasPublicacao.pdf) and the “Declaration of Potential Conflicts of Interest” (http:// www.icmje.org/conflicts-of-interest). An e-mail will be sent to the corresponding author to acknowledge receipt of the manuscript.
After publication, the authors are authorised to make their articles available in repositories of their institutions of origin, as long as they always mention where they were published and according to the Creative Commons license.

