The seroprevalence for hepatitis E viral antibodies in the northern region of Portugal (among the donor population).

Abstract

The authors have undertaken a study in the north of Portugal in what concerns the prevalence of antibodies for HEV donors. This study was transverse through observation and survey. A sample of 1.473 donors was randomly selected from among the population of donors of the Oporto Regional Blood Centre. This sample was representative of the northern region and stratified by district. The usual EIA method has been used to search for HEV antibodies. The results, which were repeatedly reactive, have been confirmed by Western Blot. The prevalence of antibodies for Hepatitis E was 2.5%. The test identified a possible cohort effect and the sample showed that the average age of the donors with or without antibodies was identical. No difference was observed regarding sex, distribution by districts or the presence of antibodies for HB virus. Hepatitis E is benign, without chronic state carrier and almost every patient presents acute symptomatology. The value of prevalence found as well as the absence of clinical symptomatology in the observed donors and the normal state of the hepatic markers, indicate that the use of blood and components obtained from this population should not be a problem. The recommendation proposed by the European Council does not mention the systematic research of HEV. However the epidemiological HEV survey is considered important from the transfusional point of view and as an indicator of the sanitary development of the population. Bearing in mind the developing status of Portugal in this area, it is of utmost importance to create the means to reach European standards.