Meningiomas: present and future.
DOI:
https://doi.org/10.20344/amp.3081Abstract
The article describes the most recent advances in the field of the embryology, physiopathology, therapy, and prognosis of meningiomas. It is assumed that the future of our knowledge of these neoplasms will be based upon the present basic and clinical research. The well known arachnoid cell origin of meningiomas is emphasized, the ultrastructure of the arachnoid villi is mentioned and the double embryological origin of the meningeal membranes--neuroectodermal and mesodermal--is stressed. Based upon personal ultrastructural and immunohistochemical studies, the probable pericytic and arachnoid origin of the so-called hemangiopericytic and sarcomatous meningiomas respectively, is reported. The several possible physiopathological mechanisms of the peritumoral oedema are summarized. Concerning the biological behaviour of meningiomas, the relevance of complete surgical resection is stressed, although new imaging or histological technics are also important in the prediction of recurrences. Lastly, regarding the management of these kind of tumors, other therapeutic procedures beyond surgery are also considered.Downloads
Downloads
How to Cite
Issue
Section
License
All the articles published in the AMP are open access and comply with the requirements of funding agencies or academic institutions. The AMP is governed by the terms of the Creative Commons ‘Attribution – Non-Commercial Use - (CC-BY-NC)’ license, regarding the use by third parties.
It is the author’s responsibility to obtain approval for the reproduction of figures, tables, etc. from other publications.
Upon acceptance of an article for publication, the authors will be asked to complete the ICMJE “Copyright Liability and Copyright Sharing Statement “(http://www.actamedicaportuguesa.com/info/AMP-NormasPublicacao.pdf) and the “Declaration of Potential Conflicts of Interest” (http:// www.icmje.org/conflicts-of-interest). An e-mail will be sent to the corresponding author to acknowledge receipt of the manuscript.
After publication, the authors are authorised to make their articles available in repositories of their institutions of origin, as long as they always mention where they were published and according to the Creative Commons license.
