Glycosylated hemoglobin - structure, clinical importance and methods of determination.
DOI:
https://doi.org/10.20344/amp.3883Abstract
Cerca de 90% da hemoglobina (Hb) dos adultos e crianças normais (com idades superiores a 6 meses) e constituída pela HbA (α2β2); a par deste componente principal, existem habitualmente duas outras fracções, a HbA2 (α2δ2), perfazendo cerca de 2,5% da Hb total e a HbF (α2ϒ2), apenas 0,2% a 0,5%. A síntese de cada uma das cadeias polipeptídicas (α, β, ϒ e δ) daqueles três componentes da hemoglobina e codificada por genes diferentes.
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