Comorbidity between hepatitis C and depression. Epidemiological and etiopathogenic aspects.
DOI:
https://doi.org/10.20344/amp.909Abstract
Neuropsychiatric symptoms are commonly associated with chronic hepatitis C virus infection (HCV). The aim of this review of the literature was to evaluate the prevalence of depression in patients with hepatitis C, as well as the proposed etiopathogenic models. A review of the literature was undertaken using the complete search strategy devised by the Cochrane Collaboration Review Group for Depression, Anxiety and Neurosis. All studies but one have shown that major depression in chronic HCV patients is significantly more common than in the general population (reported rates from 5.7% and 45%), being related with illness perception, functional disability, impaired quality of life, fatigue severity, and the presence of psychiatric comorbidity. The mechanism by which depression is related to Hepatitis C is still poorly understood. Authors address some possible mechanisms, such as the psychological impact of the knowledge that one has been infected with HCV and the direct effects of the virus itself on the Central Nervous System (eg. cytoquines).Downloads
Downloads
How to Cite
Issue
Section
License
All the articles published in the AMP are open access and comply with the requirements of funding agencies or academic institutions. The AMP is governed by the terms of the Creative Commons ‘Attribution – Non-Commercial Use - (CC-BY-NC)’ license, regarding the use by third parties.
It is the author’s responsibility to obtain approval for the reproduction of figures, tables, etc. from other publications.
Upon acceptance of an article for publication, the authors will be asked to complete the ICMJE “Copyright Liability and Copyright Sharing Statement “(http://www.actamedicaportuguesa.com/info/AMP-NormasPublicacao.pdf) and the “Declaration of Potential Conflicts of Interest” (http:// www.icmje.org/conflicts-of-interest). An e-mail will be sent to the corresponding author to acknowledge receipt of the manuscript.
After publication, the authors are authorised to make their articles available in repositories of their institutions of origin, as long as they always mention where they were published and according to the Creative Commons license.
