Mirtazapine-Induced Mania: A Case Report

Authors

  • Catarina Freitas Departamento de Psiquiatria e Saúde Mental. Centro Hospitalar de Trás-os-Montes e Alto Douro. Vila Real.
  • Rui Barranha Departamento de Psiquiatria e Saúde Mental. Centro Hospitalar do Tâmega e Sousa. Penafiel.
  • Tânia Abreu Departamento de Psiquiatria e Saúde Mental. Centro Hospitalar do Tâmega e Sousa. Penafiel.
  • Orlando von Doellinger Departamento de Psiquiatria e Saúde Mental. Centro Hospitalar do Tâmega e Sousa. Penafiel.

DOI:

https://doi.org/10.20344/amp.9916

Keywords:

Antidepressive Agents, Tricyclic/adverse effects, Bipolar Disorder/chemically induced, Mirtazapine/adverse effects

Abstract

Manic and hypomanic states associated with antidepressant treatments are relatively common; however, when specifically considering mirtazapine, those side effects are infrequent. The authors report a clinical case regarding a manic episode with dysphoric features in a patient with no personal or family previous psychiatric history. It began two weeks after starting treatment with mirtazapine up to 30 mg/day. This episode was treated discontinuing mirtazapine and initiating olanzapine (10 mg), with symptomatic remission. Mirtazapine has a specific pharmacodynamics, blocking not only post-synaptic serotonergic receptors but also α2-presynaptic adrenergic receptors. Taking this into consideration, it was hypothesized that this case could be attributed to a noradrenergic syndrome, characterized by dysphoria, irritability, insomnia and psychomotor agitation.

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Published

2019-10-01

How to Cite

1.
Freitas C, Barranha R, Abreu T, von Doellinger O. Mirtazapine-Induced Mania: A Case Report. Acta Med Port [Internet]. 2019 Oct. 1 [cited 2024 Nov. 23];32(10):671-3. Available from: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/9916

Issue

Vol. 32 No. 10 (2019): October

Section

Case Report

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