Polimorfismo do alelo HLA-B27 no desenvolvimento das espondilartropatias.

Autores

  • M J Peixoto Serviço de Epidemiologia e Biologia Molecular, Hospital de Santo Espírito, Angra do Heroísmo, Açores, Portugal.
  • T Gonzales
  • H Spinola
  • A R Couto
  • M Gantes Mora
  • A Brehm
  • M R Santos
  • F Garrett
  • J Bruges Armas

DOI:

https://doi.org/10.20344/amp.1031

Resumo

The association of HLA-B27 with ankylosing spondylitis (AS), and other spondyloarthropathies (SpA), remains as one of the strongest between HLA molecules and human disease. Since it was reported, in 1973, it has been extensively studied in order to understand the underlying pathogenic mechanism. The objective of this article is to review the current knowledge on the structure and polymorphism of HLA-B27 molecule, as well as describe the main pathogenic hypotheses trying to explain its association with AS.

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1.
Peixoto MJ, Gonzales T, Spinola H, Couto AR, Mora MG, Brehm A, Santos MR, Garrett F, Armas JB. Polimorfismo do alelo HLA-B27 no desenvolvimento das espondilartropatias. Acta Med Port [Internet]. 31 de Agosto de 2005 [citado 1 de Julho de 2024];18(4):283-93. Disponível em: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/1031

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