Sistema renina-angiotensina-aldosterona e sua modulação farmacológica.

Autores

  • Anabela Giestas Serviço de Endocrinologia, Diabetes e Metabolismo, Hospital de Santo António (CHP), Porto.
  • Isabel Palma
  • Maria Helena Ramos

DOI:

https://doi.org/10.20344/amp.687

Resumo

The renin-angiotensin-aldosterone system (RAAS) is a neuroendocrine complex system that regulates the modulation of salt and water homeostasis, and regulation of blood pressure. Through its multiple interactions it protects the endothelium, heart, brain and kidney. In addition, the RAAS regulates the vascular response to injury and inflammation. Chronic activation/dysregulation of the RAAS leads to hypertension and perpetuates a cascade of proinflammatory, prothrombotic and atherogenic effects associated with endorgan damage (heart, brain, kidney, endothelium). Consequently, the RAAS is an important therapeutic target in these situations. This article presents an overview of physiology, pathophysiology and pharmacologic modulation of the RAAS.

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1.
Giestas A, Palma I, Ramos MH. Sistema renina-angiotensina-aldosterona e sua modulação farmacológica. Acta Med Port [Internet]. 30 de Julho de 2010 [citado 26 de Setembro de 2024];23(4):677-88. Disponível em: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/687

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