Influência da replicação do vírus da hepatite C em linfoma esplénico de células vilosas.

Autores

  • Joana Nunes Serviços de Gastrenterologia e Hepatologia e de Serviço de Hematologia, Hospital de Santa Maria, Lisboa.
  • Rui Tato Marinho
  • João Raposo
  • José Velosa

DOI:

https://doi.org/10.20344/amp.703

Resumo

The association between hepatitis C and B-cell non-Hodgkin lymphoma (NHL) has been suggested by several studies. We report the case of a 70 year-old patient with the diagnosis of chronic hepatitis C and splenic lymphoma with villous lymphocytes, who had undergone splenectomy and chemotherapy with fludarabine, with transient effectiveness. He was sent to our Hepatology Clinic for the treatment of hepatitis C, and Pegylated Interferon and Ribavirin were started. He had virological and hematological response (63% of villous lymphocytes in the peripheral blood at the beginning of therapy and 0% at the end). With the suspension of antiviral therapy, recurrence of HCV infection and reappearance of atypical lymphocytes (24%) were observed, and Pegylated Interferon was restarted, with good response. The relationship between viral and hematologic response (remission and relapse) supports the hypothesis that hepatitis C virus has an active role in the pathogenesis of splenic lymphoma with villous lymphocytes.

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1.
Nunes J, Tato Marinho R, Raposo J, Velosa J. Influência da replicação do vírus da hepatite C em linfoma esplénico de células vilosas. Acta Med Port [Internet]. 22 de Outubro de 2010 [citado 18 de Julho de 2024];23(5):941-4. Disponível em: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/703

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